ArticleMolecular psychiatry2021
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy.Translational psychiatry · 2022Article
- Early-Life Environment Influence on Late-Onset Alzheimer's Disease.Frontiers in cell and developmental biology · 2022Review
- Dysfunction of the retromer complex system contributes to amyloid and tau pathology in a stem cell model of Down syndrome.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Effects of safflower yellow on cholesterol levels in serum and brain tissue of APP/PS1 mice.Metabolic brain disease · 2021Article
- Maternal high sugar and fat diet benefits offspring brain function via targeting on the gut-brain axis.Aging · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Maternal history for sporadic Alzheimer's disease (AD) predisposes the offspring to the disease later in life. However, the mechanisms behind this phenomenon are still unknown. Lifestyle and nutrition can directly modulate susceptibility to AD. Herein we investigated whether gestational high fat diet influences the offspring susceptibility to AD later in life. Triple transgenic dams were administered high fat diet or regular chow throughout 3 weeks gestation. Offspring were fed regular chow throughout their life and tested for spatial learning and memory, brain amyloidosis, tau pathology, and synaptic function. Gestational high fat diet attenuated memory decline, synaptic dysfunction, amyloid-β and tau neuropathology in the offspring by transcriptional regulation of BACE-1, CDK5, and tau gene expression via the upregulation of FOXP2 repressor. Gestational high fat diet protects offspring against the development of the AD phenotype. In utero dietary intervention could be implemented as preventative strategy against AD.
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