ArticleScientific reports2019
Proteomic enzyme analysis of the marine fungus Paradendryphiella salina reveals alginate lyase as a minimal adaptation strategy for brown algae degradation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Bioconversion of macroalgae by enzymes from associated fungi into hydrolysates with cumulative antioxidant and antiglycemic properties for effective diabetes management.Archives of microbiology · 2026Article
- Comparative Genomics Analysis and Pathogenicity Assessment ofPlants (Basel, Switzerland) · 2026Article
- Inferring an ancestral alginate lyase for improved stability and high-level expression using fed-batch fermentation.Frontiers in microbiology · 2026Article
- Diatom heterotrophy on brown algal polysaccharides emerged through horizontal gene transfer, gene duplication, and neofunctionalization.PLoS biology · 2025Article
- Unraveling the molecular mechanism of polysaccharide lyases for efficient alginate degradation.Nature communications · 2025Article
- Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Comprehensive Nutritional and Functional Characterization of Novel Mycoprotein Derived from the Bioconversion ofFoods (Basel, Switzerland) · 2024Article
- Blue Biotechnology: Marine Bacteria Bioproducts.Microorganisms · 2024Review
- Influence of Salinity on the Extracellular Enzymatic Activities of Marine Pelagic Fungi.Journal of fungi (Basel, Switzerland) · 2024Article
- Fungal pectinases: an insight into production, innovations and applications.World journal of microbiology & biotechnology · 2023Review
- Diversity of fungi from marine inundated wood from the Bay of Fundy, Nova Scotia, Canada.Botanica marina · 2023Article
- Fungal Proteins fromMolecules (Basel, Switzerland) · 2022Article
- Alginate Lyases from Marine Bacteria: An Enzyme Ocean for Sustainable Future.Molecules (Basel, Switzerland) · 2022Review
- Discovery of a Novel Glucuronan Lyase System inApplied and environmental microbiology · 2022Article
- Discovery of novel secretome CAZymes fromFrontiers in bioengineering and biotechnology · 2022Article
- Toward Understanding the Alginate Catabolism inFrontiers in bioengineering and biotechnology · 2022Article
- A Comprehensive Insight into Fungal Enzymes: Structure, Classification, and Their Role in Mankind's Challenges.Journal of fungi (Basel, Switzerland) · 2021Review
- An individual alginate lyase is effective in the disruption of Laminaria digitata recalcitrant cell wall.Scientific reports · 2021Article
- Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration.Heliyon · 2021Review
- Specificities and Synergistic Actions of Novel PL8 and PL7 Alginate Lyases from the Marine FungusJournal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We set out to investigate the genetic adaptations of the marine fungus Paradendryphiella salina CBS112865 for degradation of brown macroalgae. We performed whole genome and transcriptome sequencing and shotgun proteomic analysis of the secretome of P. salina grown on three species of brown algae and under carbon limitation. Genome comparison with closely related terrestrial fungi revealed that P. salina had a similar but reduced CAZyme profile relative to the terrestrial fungi except for the presence of three putative alginate lyases from Polysaccharide Lyase (PL) family 7 and a putative PL8 with similarity to ascomycete chondroitin AC lyases. Phylogenetic and homology analyses place the PL7 sequences amongst mannuronic acid specific PL7 proteins from marine bacteria. Recombinant expression, purification and characterization of one of the PL7 genes confirmed the specificity. Proteomic analysis of the P. salina secretome when growing on brown algae, revealed the PL7 and PL8 enzymes abundantly secreted together with enzymes necessary for degradation of laminarin, cellulose, lipids and peptides. Our findings indicate that the basic CAZyme repertoire of saprobic and plant pathogenic ascomycetes, with the addition of PL7 alginate lyases, provide P. salina with sufficient enzymatic capabilities to degrade several types of brown algae polysaccharides.
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