ArticleScientific reports2019
Surface Enhanced Raman Spectroscopy for Single Molecule Protein Detection.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Spectral Super-Resolution Colloidal SERS Spectroscopy for Multiplexed Detection of Protein Biomarkers.Nano letters · 2026Article
- Engineering Nanomaterials for Raman Bioimaging and Theranostics: Advances, Challenges, and Future Directions.ACS omega · 2025Review
- A chemical autonomous robotic platform for end-to-end synthesis of nanoparticles.Nature communications · 2025Article
- Discrimination of Dengue Diseases in Children Using Surface-Enhanced Raman Spectroscopy Coupled with Machine Learning Approaches.Analytical chemistry · 2025Article
- Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media.Nano letters · 2025Article
- Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media.bioRxiv : the preprint server for biology · 2025Article
- Gold Nanoprism Enhanced SERS Aptasensor for Simultaneous Detection of Thrombin and VEGF.Sensors and actuators. B, Chemical · 2025Article
- Multiplexed SERS Detection of Serum Cardiac Markers Using Plasmonic Metasurfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Analyzing aptamer structure and interactions: in silico modelling and instrumental methods.Biophysical reviews · 2024Review
- Oblique Deposited Ultra-Thin Silver Films on Polymer Gratings for Sensitive SERS Performance.Nanomaterials (Basel, Switzerland) · 2024Article
- Surface-Enhanced Raman Spectroscopy at the Interface between Drug Discovery and Personalized Medicine.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Review
- Tuning Nanographene-Enhanced Raman Scattering for Rapid Label-Free Detection of Amino Acids.ACS applied materials & interfaces · 2024Article
- Black Silicon Surface-Enhanced Raman Spectroscopy Biosensors: Current Advances and Prospects.Biosensors · 2024Review
- Accessible Double Nanohole Raman Tweezer Analysis of Single Nanoparticles.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Quasi-spherical silver nanoparticles for human prolactin detection by surface-enhanced Raman spectroscopy.RSC advances · 2024Article
- Contemporary applications of vibrational spectroscopy in plant stresses and phenotyping.Frontiers in plant science · 2024Review
- On the Measurements of the Surface-Enhanced Raman Scattering Spectrum: Effective Enhancement Factor, Optical Configuration, Spectral Distortion, and Baseline Variation.Nanomaterials (Basel, Switzerland) · 2023Article
- Plasmonic Nanostructure Biosensors: A Review.Sensors (Basel, Switzerland) · 2023Review
- ReSMolecules (Basel, Switzerland) · 2023Article
- Silver-based SERS substrates fabricated using a 3D printed microfluidic device.Beilstein journal of nanotechnology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A two-step process of protein detection at a single molecule level using SERS was developed as a proof-of-concept platform for medical diagnostics. First, a protein molecule was bound to a linker in the bulk solution and then this adduct was chemically reacted with the SERS substrate. Traut's Reagent (TR) was used to thiolate Bovine serum albumin (BSA) in solution followed by chemical cross linking to a gold surface through a sulfhydryl group. A Glycine-TR adduct was used as a control sample to identify the protein contribution to the SER spectra. Gold SERS substrates were manufactured by electrochemical deposition. Solutions at an ultralow concentration were used for attaching the TR adducts to the SERS substrate. Samples showed the typical behavior of a single molecule SERS including spectral fluctuations, blinking and Raman signal being generated from only selected points on the substrate. The fluctuating SER spectra were examined using Principle Component Analysis. This unsupervised statistics allowed for the selecting of spectral contribution from protein moiety indicating that the method was capable of detecting a single protein molecule. Thus we have demonstrated, that the developed two-step methodology has the potential as a new platform for medical diagnostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.