ArticleProceedings of the National Academy of Sciences of the United States of America2019
Prenatal exposure to organophosphate pesticides and functional neuroimaging in adolescents living in proximity to pesticide application.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 97 citations in OpenAlex.
- Associations of Exposure to Common Plasticizers and Organophosphate Pesticides during Pregnancy and in Childhood with Cognitive Performance in Adolescents: A Population-Based Study.Environmental science & technology · 2026Article
- Brevetoxins and emergency department visits among children: A case-crossover study of Florida red tides.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Advancing understanding of the mechanisms of autism spectrum disorder through perinatal risk factors.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Enzyme Immobilization by Hydrogen-Bonded Organic Framework for the Construction of Plant-Wearable Sensor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Environmental and Human Health Impacts of Agricultural Pesticides on BIPOC Communities in the United States: A Review from an Environmental Justice Perspective.International journal of environmental research and public health · 2025Review
- Temporal trends of agricultural organophosphate pesticide use in California and proximity to pregnant people in 2021.BMC public health · 2025Article
- Environmental adversity, endoplasmic reticulum stress, and neurogenesis.Neurotoxicology · 2025Review
- Residential proximity to agricultural herbicide and fungicide applications and dust levels in homes of California children.Environment international · 2024Article
- Exposure to Endocrine Disruptors in Early life and Neuroimaging Findings in Childhood and Adolescence: a Scoping Review.Current environmental health reports · 2024Article
- Childhood exposure to organophosphate pesticides: Functional connectivity and working memory in adolescents.Neurotoxicology · 2024Article
- Prenatal and childhood exposure to organophosphate pesticides and functional brain imaging in young adults.Environmental research · 2024Article
- Child exposure to organophosphate and pyrethroid insecticides measured in urine, wristbands, and household dust and its implications for child health in South Africa: A panel study.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-Term Epileptic Seizure Activity, Neurologic Dysfunction and Neurodegeneration.The Journal of pharmacology and experimental therapeutics · 2024Article
- Article
- Disparities in Toxic Chemical Exposures and Associated Neurodevelopmental Outcomes: A Scoping Review and Systematic Evidence Map of the Epidemiological Literature.Environmental health perspectives · 2023Article
- Pyrethroid and Chlorpyrifos Pesticide Exposure, General Intellectual Abilities, and Executive Functions of School Children from Montevideo, Uruguay.International journal of environmental research and public health · 2023Article
- Contributions of nearby agricultural insecticide applications to indoor residential exposures.Environment international · 2023Article
- Organophosphorus Pesticide Exposure at 17 Weeks' Gestation and Odds of Offspring Attention-Deficit/Hyperactivity Disorder Diagnosis in the Norwegian Mother, Father, and Child Cohort Study.International journal of environmental research and public health · 2022Article
- Pesticide exposure and cortical brain activation among farmworkers in Costa Rica.Neurotoxicology · 2022Article
- Cognitive Impairment and Neurodegenerative Diseases Development Associated with Organophosphate Pesticides Exposure: a Review Study.Neurotoxicity research · 2022Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
We have reported consistent associations of prenatal organophosphate pesticide (OP) exposure with poorer cognitive function and behavior problems in our Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a birth cohort of Mexican American youth in California's agricultural Salinas Valley. However, there is little evidence on how OPs affect neural dynamics underlying associations. We used functional near-infrared spectroscopy (fNIRS) to measure cortical activation during tasks of executive function, attention, social cognition, and language comprehension in 95 adolescent CHAMACOS participants. We estimated associations of residential proximity to OP use during pregnancy with cortical activation in frontal, temporal, and parietal regions using multiple regression models, adjusting for sociodemographic characteristics. OP exposure was associated with altered brain activation during tasks of executive function. For example, with a 10-fold increase in total OP pesticide use within 1 km of maternal residence during pregnancy, there was a bilateral decrease in brain activation in the prefrontal cortex during a cognitive flexibility task (β = -4.74; 95% CI: -8.18, -1.31 and β = -4.40; 95% CI: -7.96, -0.84 for the left and right hemispheres, respectively). We also found that prenatal OP exposure was associated with sex differences in brain activation during a language comprehension task. This first functional neuroimaging study of prenatal OP exposure suggests that pesticides may impact cortical brain activation, which could underlie previously reported OP-related associations with cognitive and behavioral function. Use of fNIRS in environmental epidemiology offers a practical alternative to neuroimaging technologies and enhances our efforts to assess the impact of chemical exposures on neurodevelopment.
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