Evidence map›Paper›PMID 31451634›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells.

Christopher J Lingle, Pedro L Martinez-Espinosa, Aizhen Yang-Hood, Luis E Boero, Shelby Payne, Dora Persic, Babak V-Ghaffari, Maolei Xiao, Yu Zhou, Xiao-Ming Xia and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The mechanism of CaThe Journal of biological chemistry · 2025
    Article
  7. Article
  8. Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024
    Review
  9. Article
  10. A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Excess extracellular KCommunications biology · 2021
    Article
  18. Article
  19. Review
  20. High-Resolution Structures of KHandbook of experimental pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher J LingleDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110; clingle@morpheus.wustl.edu rutherfordmark@wustl.edu.ORCID 0000-0002-9916-3795
Pedro L Martinez-EspinosaDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.
Aizhen Yang-HoodDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.
Luis E BoeroDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-1758-616X
Shelby PayneDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.
Dora PersicDepartment of Otorhinolaryngology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands.
Babak V-GhaffariDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.
Maolei XiaoDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.
Yu ZhouDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-1407-6140
Xiao-Ming XiaDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.
Sonja J PyottDepartment of Otorhinolaryngology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands.
Mark A RutherfordDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110; clingle@morpheus.wustl.edu rutherfordmark@wustl.edu.ORCID 0000-0002-2627-6254

Funding

SLO family potassium channels: function and physiologyR35GM118114 · NIGMS · WASHINGTON UNIVERSITY · PI LINGLE, CHRISTOPHER J · 2016 to 2025
$6.9M
EXCITATION AND EXCITOTOXICITY IN TYPE I COCHLEAR AFFERENTS: SYNAPTIC STRUCTURE AND FUNCTIONR01DC014712 · NIDCD · WASHINGTON UNIVERSITY · PI Mark Allen Rutherford · 2016 to 2026
$5.6M
The role of FGF-mediated fast inactivation of Nav channels in cell excitabilityR01NS100695 · NINDS · WASHINGTON UNIVERSITY · PI LINGLE, CHRISTOPHER J · 2017 to 2020
$1.4M
NIDCD NIH HHS R01 DC014712NIGMS NIH HHS R35 GM118114NINDS NIH HHS R01 NS100695
6 · The paper itself

Abstract

The perception of sound relies on sensory hair cells in the cochlea that convert the mechanical energy of sound into release of glutamate onto postsynaptic auditory nerve fibers. The hair cell receptor potential regulates the strength of synaptic transmission and is shaped by a variety of voltage-dependent conductances. Among these conductances, the Ca

Indexed as

AnimalsCalciumFemaleHair Cells, Auditory, InnerIon Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsMaleMembrane PotentialsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutSynaptic TransmissionTranscriptomeCalciumLarge-Conductance Calcium-Activated Potassium ChannelsLRRC52 protein, mouseMembrane Proteinsauxiliary subunitsBK channelsgamma subunitsinner hair cellsLRRC52

Identifiers

PMID31451634
PMCPMC6744894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.