Evidence map›Paper›PMID 31451631›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors.

Tobias Hassler, Emanuel Urmann, Sebastian Teschner, Christine Federle, Thamotharampillai Dileepan, Kilian Schober, Marc K Jenkins, Dirk H Busch, Maria Hinterberger, Ludger Klein

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  4. The partitioning of TCR repertoires by thymic selection.The Journal of experimental medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tobias HasslerInstitute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Emanuel UrmannInstitute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Sebastian TeschnerInstitute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Christine FederleInstitute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Thamotharampillai DileepanCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Kilian SchoberInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
Marc K JenkinsCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-8009-7655
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.ORCID 0000-0001-8713-093X
Maria HinterbergerInstitute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Ludger KleinInstitute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany; ludger.klein@med.lmu.de.
Ludwig-Maximilians-Universität München · DEUniversity of Minnesota · USGerman Center for Infection Research · DEInstitute of Medical Microbiology and Hygiene · DE

Funding

Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 1993 to 2023
$31.1M
NIAID NIH HHS P01 AI035296
6 · The paper itself

Abstract

Deletion or T

Indexed as

AnimalsAutoantigensCell DifferentiationCell LineageCentral Nervous SystemClonal DeletionForkhead Transcription FactorsGene Rearrangement, T-LymphocyteHistocompatibility Antigens Class IILymphocyte ActivationMiceMice, KnockoutMice, TransgenicMyelin Proteolipid ProteinReceptors, Antigen, T-CellThymocytesAutoantigensForkhead Transcription FactorsFoxp3 protein, mouseHistocompatibility Antigens Class IIMyelin Proteolipid ProteinPlp1 protein, mouseReceptors, Antigen, T-Cellclonal deletionclonal diversionMHC class II tetramerregulatory T cellT cell tolerance

Identifiers

PMID31451631
PMCPMC6744931
OpenAlexW2971002670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.