ArticleInfection and immunity2019
Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia.
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In one paragraph
Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.Nature communications · 2026Article
- An Update on IL-22 Therapies in Alcohol-Associated Liver Disease and Beyond.The American journal of pathology · 2026Review
- IL-22 in Atopic Dermatitis.Cells · 2024Review
- IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury.The American journal of pathology · 2024Article
- Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders.Nature communications · 2024Article
- Review
- Mechanisms of Lung and Intestinal Microbiota and Innate Immune Changes Caused by Pathogenic Enterococcus Faecalis Promoting the Development of Pediatric Pneumonia.Microorganisms · 2023Article
- Current Knowledge of Th22 Cell and IL-22 Functions in Infectious Diseases.Pathogens (Basel, Switzerland) · 2023Review
- Disease tolerance: a protective mechanism of lung infections.Frontiers in cellular and infection microbiology · 2023Review
- Interleukin-22: a potential therapeutic target in atherosclerosis.Molecular medicine (Cambridge, Mass.) · 2021Review
- Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration.Cell reports. Medicine · 2021Article
- Stress-induced differential gene expression in cardiac tissue.Scientific reports · 2021Article
- IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology.Frontiers in immunology · 2021Review
- Formula Diet Alters the Ileal Metagenome and Transcriptome at Weaning and during the Postweaning Period in a Porcine Model.mSystems · 2020Article
- IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Giraldina Trevejo-NunezDivision of Infectious Diseases. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA giraldina.trevejo@pitt.edu.
Waleed ElsegeinyUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1170-4890
Felix E Y AggorDivision of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jamie L TweedleDivision of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Zoe KaplanUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pranali GandhiDivision of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Patricia CastilloUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Annabel FergusonDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
John F AlcornUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kong ChenDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jay K KollsUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sarah L GaffenDivision of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USChildren's Hospital of Pittsburgh · USTulane University · US
Funding
Autoimmunity and Immunopathology Training ProgramT32AI089443 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2010 to 2024
$6.6MTraining in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3MHost and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6MInfluenza A Inhibits TH17 Host Defense Against Bacterial PneumoniaR01HL107380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2012 to 2024
$5.4MTh17 Cytokines and Lung ImmunityR37HL079142 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 2010 to 2017
$3.6MRole of IL-22/IL-22RA2 during pneumococcal pneumoniaK01HL135476 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREVEJO-NUNEZ, GIRALDINA · 2017 to 2021
$836kDomain-specific role of IL-17RA in controlling Klebsiella pneumoniae lung infectionR03HL154231 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREVEJO-NUNEZ, GIRALDINA · 2020 to 2021
$157kNHLBI NIH HHS K01 HL135476NHLBI NIH HHS R01 HL107380NHLBI NIH HHS R03 HL154231NHLBI NIH HHS R35 HL139930NHLBI NIH HHS R37 HL079142NIAID NIH HHS T32 AI089443NIDCR NIH HHS R37 DE022550
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCell LineDisease SusceptibilityEpithelial CellsGene Expression RegulationInterleukin-22InterleukinsLeukocyte Common AntigensLungMacrophagesMiceMice, KnockoutOxidation-ReductionPhosphorylationPneumonia, PneumococcalReceptors, InterleukinInterleukin-22interleukin-22 receptorInterleukinsLeukocyte Common AntigensPtprc protein, mouseReceptors, Interleukinhost defenseIL-22BPOXPHOS
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.