Evidence map›Paper›PMID 31451615›Full record

ArticleThe Journal of cell biology2019

A theory of centriole duplication based on self-organized spatial pattern formation.

Daisuke Takao, Shohei Yamamoto, Daiju Kitagawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  15. Human centrosome organization and function in interphase and mitosis.Seminars in cell & developmental biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daisuke TakaoGraduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan dtakao@mol.f.u-tokyo.ac.jp.ORCID 0000-0001-6136-6733
Shohei YamamotoGraduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
Daiju KitagawaGraduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan dkitagawa@mol.f.u-tokyo.ac.jp.ORCID 0000-0003-2509-5977

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In each cell cycle, centrioles are duplicated to produce a single copy of each preexisting centriole. At the onset of centriole duplication, the master regulator Polo-like kinase 4 (Plk4) undergoes a dynamic change in its spatial pattern around the preexisting centriole, forming a single duplication site. However, the significance and mechanisms of this pattern transition remain unknown. Using super-resolution imaging, we found that centriolar Plk4 exhibits periodic discrete patterns resembling pearl necklaces, frequently with single prominent foci. Mathematical modeling and simulations incorporating the self-organization properties of Plk4 successfully generated the experimentally observed patterns. We therefore propose that the self-patterning of Plk4 is crucial for the regulation of centriole duplication. These results, defining the mechanisms of self-organized regulation, provide a fundamental principle for understanding centriole duplication.

Indexed as

CentriolesHCT116 CellsHumansProtein Serine-Threonine KinasesPLK4 protein, humanProtein Serine-Threonine Kinases

Identifiers

PMID31451615
PMCPMC6829667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.