Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
GABAergic Inhibition Gates Perceptual Awareness During Binocular Rivalry.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06234501 (Testing the Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Testing the Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism
Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.Human psychopharmacology · 2022Trial
- Perceiving the uncertain: predictive coding and individual differences in the dynamics of multistable perception.Cognitive processing · 2026Review
- Efficacy, safety, and tolerability of arbaclofen in Autistic children and adolescents, the AIMS-2-TRIALS-CT1: a randomized, double-blind, placebo-controlled phase II trial.EClinicalMedicine · 2026Article
- Circuit dynamics of binocular conflict in mouse primary visual cortex.Frontiers in systems neuroscience · 2026Article
- Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD.Translational psychiatry · 2025Article
- Responses to conflicting binocular stimuli in mouse primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- An anti-Hebbian model for binocular visual plasticity and its attentional modulation.Communications biology · 2025Article
- Anodal transcranial direct current stimulation does not alter GABA concentration or functional connectivity in the normal visual cortex.Frontiers in neuroscience · 2025Article
- The complexity of human subjective experience during binocular rivalry.Neuroscience of consciousness · 2025Article
- Enhanced motor noise in an autism subtype with poor motor skills.Molecular autism · 2024Article
- Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024Article
- Binocular rivalry under naturalistic geometry: Evidence from worlds simulated in virtual reality.PNAS nexus · 2024Article
- The neurochemistry of learning-driven sensory eye dominance plasticity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A theory of autism bridging across levels of description.Trends in cognitive sciences · 2023Review
- Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations.International journal of molecular sciences · 2023Review
- Short-term homeostatic visual neuroplasticity in adolescents after two hours of monocular deprivation.IBRO neuroscience reports · 2023Article
- Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure.Translational psychiatry · 2023Article
- Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAbioRxiv : the preprint server for biology · 2023Article
- New insights into binocular rivalry from the reconstruction of evolving percepts using model network dynamics.Frontiers in computational neuroscience · 2023Article
- InFoRM (Indicate-Follow-Replay-Me): A novel method to measure perceptual multistability dynamics using continuous data tracking and validated estimates of visual introspection.Consciousness and cognition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Binocular rivalry is a classic experimental tool to probe the neural machinery of perceptual awareness. During rivalry, perception alternates between the two eyes, and the ebb and flow of perception is modeled to rely on the strength of inhibitory interactions between competitive neuronal populations in visual cortex. As a result, rivalry has been suggested as a noninvasive perceptual marker of inhibitory signaling in visual cortex, and its putative disturbance in psychiatric conditions, including autism. Yet, direct evidence causally implicating inhibitory signaling in the dynamics of binocular rivalry is currently lacking. We previously found that people with higher GABA levels in visual cortex, measured using magnetic resonance spectroscopy, have stronger perceptual suppression during rivalry. Here, we present direct causal tests of the impact of GABAergic inhibition on rivalry dynamics, and the contribution of specific GABA receptors to these dynamics. In a crossover pharmacological design with male and female adult participants, we found that drugs that modulate the two dominant GABA receptor types in the brain, GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.