ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Adult neuroplasticity employs developmental mechanisms.Frontiers in systems neuroscience · 2022Pooled it
- Noise-induced hearing loss delays auditory learning and reduces the influence of acoustic evidence on choice.bioRxiv : the preprint server for biology · 2026Article
- Perceptual training selectively strengthens top-down signaling to sensory cortex.bioRxiv : the preprint server for biology · 2026Article
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neural Correlates of Perceptual Plasticity in the Auditory Midbrain and Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils.Current biology : CB · 2024Article
- Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cortical determinants of loudness perception and auditory hypersensitivity.bioRxiv : the preprint server for biology · 2024Article
- Neural correlates of flexible sound perception in the auditory midbrain and thalamus.bioRxiv : the preprint server for biology · 2024Article
- An Animal Model of Neonatal Intensive Care Unit Exposure to Light and Sound in the Preterm Infant.Integrative and comparative biology · 2023Article
- Social play behavior shapes the development of prefrontal inhibition in a region-specific manner.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAbioRxiv : the preprint server for biology · 2023Article
- A Redundant Cortical Code for Speech Envelope.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Superior semicircular canal dehiscence and subsequent closure induces reversible impaired decision-making.Frontiers in neurology · 2023Article
- Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.Nature communications · 2022Article
- Article
- Time Course of Activity-Dependent Changes in Auditory Nerve Synapses Reveals Multiple Underlying Cellular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Development of Auditory Cortex Circuits.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Cranioplastic Surgery and Acclimation Training for Awake Mouse fMRI.Bio-protocol · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Transient periods of childhood hearing loss can induce deficits in aural communication that persist long after auditory thresholds have returned to normal, reflecting long-lasting impairments to the auditory CNS. Here, we asked whether these behavioral deficits could be reversed by treating one of the central impairments: reduction of inhibitory strength. Male and female gerbils received bilateral earplugs to induce a mild, reversible hearing loss during the critical period of auditory cortex development. After earplug removal and the return of normal auditory thresholds, we trained and tested animals on an amplitude modulation detection task. Transient developmental hearing loss induced both learning and perceptual deficits, which were entirely corrected by treatment with a selective GABA reuptake inhibitor (SGRI). To explore the mechanistic basis for these behavioral findings, we recorded the amplitudes of GABA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.