Evidence map›Paper›PMID 31451564›Full record

ArticleMolecular cancer therapeutics2019

Short- and Long-Term Effects of CDK4/6 Inhibition on Early-Stage Breast Cancer.

William B Kietzman, Garrett T Graham, Virginie Ory, Ghada M Sharif, Max H Kushner, Gregory T Gallanis, Bhaskar Kallakury, Anton Wellstein, Anna T Riegel

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

William B KietzmanDepartment of Oncology, Georgetown University, Washington, District of Columbia.
Garrett T GrahamDepartment of Oncology, Georgetown University, Washington, District of Columbia.ORCID 0000-0002-1097-0962
Virginie OryDepartment of Oncology, Georgetown University, Washington, District of Columbia.
Ghada M SharifDepartment of Oncology, Georgetown University, Washington, District of Columbia.
Max H KushnerDepartment of Oncology, Georgetown University, Washington, District of Columbia.
Gregory T GallanisDepartment of Oncology, Georgetown University, Washington, District of Columbia.
Bhaskar KallakuryDepartment of Pathology, Georgetown University, Washington, District of Columbia.
Anton WellsteinDepartment of Oncology, Georgetown University, Washington, District of Columbia.ORCID 0000-0002-0570-4950
Anna T RiegelDepartment of Oncology, Georgetown University, Washington, District of Columbia. ariege01@georgetown.edu.
Georgetown University · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
(PQ #8) Biomarkers of efficacy and adverse events due to treatment with immune checkpoint inhibitorsR01CA231291 · NCI · GEORGETOWN UNIVERSITY · PI ATKINS, MICHAEL BENJAMIN, WELLSTEIN, ANTON · 2018 to 2022
$2.6M
(PQ6) Molecular Mechanisms Driving Benign to Malignant Transitions in Breast CancerR01CA205632 · NCI · GEORGETOWN UNIVERSITY · PI RIEGEL, ANNA TATE · 2016 to 2020
$2.3M
Development of clinically relevant models of DCISR21CA226542 · NCI · GEORGETOWN UNIVERSITY · PI RIEGEL, ANNA TATE · 2019 to 2020
$369k
Role of AIB1 in YAP/TAZ-TEAD signaling in progression of early stage breast cancerF31CA232664 · NCI · GEORGETOWN UNIVERSITY · PI KUSHNER, MAX HARLEY · 2018 to 2019
$50k
NCI NIH HHS F31 CA232664NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA205632NCI NIH HHS R01 CA231291NCI NIH HHS R21 CA226542NCI NIH HHS T32 CA009686
6 · The paper itself

Abstract

CDK4/6 inhibitors are used in the treatment of advanced estrogen receptor (ER)(+) breast cancer. Their efficacy in ER(-) and early-stage breast cancer is currently under investigation. Here, we show that palbociclib, a CDK4/6 inhibitor, can inhibit both progression of ductal carcinoma

Indexed as

AnimalsBreast NeoplasmsCell ProliferationCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6FemaleHumansMiceMice, NudeNeoplasm StagingCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6

Identifiers

PMID31451564
PMCPMC6891167
OpenAlexW2970179116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.