Evidence map›Paper›PMID 31451537›Full record

ReviewCold Spring Harbor perspectives in medicine2019

Modeling Leukemia with Human Induced Pluripotent Stem Cells.

Eirini P Papapetrou

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Eirini P PapapetrouDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA eirini.papapetrou@mssm.edu.

Funding

Dissecting splicing factor mutations in iPSCsR01HL137219 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PAPAPETROU, EIRINI, YEO, EUGENE WEI-MING · 2017 to 2020
$3.2M
Identification of therapeutic targets for leukemia stem cells in AML-iPSC modelsR01CA225231 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KHARAS, MICHAEL, PAPAPETROU, EIRINI · 2018 to 2022
$3.2M
Novel Spliceosomal Defects in Myelodysplastic SyndromesR01HL132071 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MACIEJEWSKI, JAROSLAW P., PADGETT, RICHARD A · 2016 to 2019
$2.4M
Modeling chromosome 7 loss in Myelodysplasia-iPSCsR01HL121570 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PAPAPETROU, EIRINI · 2014 to 2018
$2.1M
NCI NIH HHS R01 CA225231NHLBI NIH HHS R01 HL121570NHLBI NIH HHS R01 HL132071NHLBI NIH HHS R01 HL137219
6 · The paper itself

Abstract

The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies. Here we discuss practical aspects of iPSC modeling of malignant diseases, review recent studies, and discuss the new opportunities that iPSC models offer, as well as their current limitations and prospects for future development.

Indexed as

Models, BiologicalAnimalsDisease Models, AnimalGenetic EngineeringHematopoiesisHumansInduced Pluripotent Stem CellsLeukemia

Identifiers

PMID31451537
PMCPMC6886454

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.