Evidence map›Paper›PMID 31451520›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2019

Autofluorescence Imaging to Monitor the Progression of Oral Potentially Malignant Disorders.

Katelin D Cherry, Richard A Schwarz, Eric C Yang, Imran S Vohra, Hawraa Badaoui, Michelle D Williams, Nadarajah Vigneswaran, Ann M Gillenwater, Rebecca Richards-Kortum

Open access · bronzeAbstract read
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Katelin D CherryDepartment of Bioengineering, Rice University, Houston, Texas.
Richard A SchwarzDepartment of Bioengineering, Rice University, Houston, Texas.
Eric C YangDepartment of Bioengineering, Rice University, Houston, Texas.
Imran S VohraDepartment of Bioengineering, Rice University, Houston, Texas.
Hawraa BadaouiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Michelle D WilliamsDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Nadarajah VigneswaranThe University of Texas Health Science Center School of Dentistry, Houston, Texas.
Ann M GillenwaterDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Rebecca Richards-KortumDepartment of Bioengineering, Rice University, Houston, Texas. rkortum@rice.edu.
Rice University · USThe University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · USThe University of Texas Health Science Center · US

Funding

Optical Systems for In Vivo Molecular Imaging of CancerR01CA103830 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI RICHARDS-KORTUM, REBECCA R. · 2004 to 2015
$12.4M
(PQC2) Optical Hallmarks of Aggressive Clones Within Oral Field CancerizationR01CA185207 · NCI · RICE UNIVERSITY · PI GILLENWATER, ANN M, RICHARDS-KORTUM, REBECCA R. · 2014 to 2017
$2.6M
Aptamer mediated targeting of Fanconi Anemia oral cancer initiating cellsR01DE024392 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ANNAPRAGADA, ANANTH V, VIGNESWARAN, NADARAJAH · 2014 to 2017
$1.5M
An Automated, Optical Imaging Platform for Early Detection of Oral NeoplasiaF30CA213922 · NCI · RICE UNIVERSITY · PI YANG, ERIC · 2017 to 2018
$96k
NCI NIH HHS F30 CA213922NCI NIH HHS R01 CA103830NCI NIH HHS R01 CA185207NIDCR NIH HHS R01 DE024392
6 · The paper itself

Abstract

Patients with oral potentially malignant disorders (OPMD) must undergo regular clinical surveillance to ensure that any progression to malignancy is detected promptly. Autofluorescence imaging (AFI) is an optical modality that can assist clinicians in detecting early cancers and high-grade dysplasia. Patients with OPMD undergoing surveillance for the development of oral cancer were examined using AFI at successive clinic visits. Autofluorescence images acquired at 133 clinical visits from sites in 15 patients who met inclusion criteria were analyzed quantitatively using an algorithm to calculate the red-to-green pixel intensity (RG ratio). A quantitative AFI threshold for high risk of progression was defined based on the RG ratio and was compared with expert clinical impression and with histopathology when available. Patients were divided into two groups based on their endpoint: surveillance (

Indexed as

Disease ProgressionEarly Detection of CancerHumansHyperplasiaLongitudinal StudiesMouth NeoplasmsOptical ImagingPrecancerous ConditionsPrognosisRetrospective Studies

Identifiers

PMID31451520
PMCPMC7319038
OpenAlexW2970801808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.