ArticleDiagnostic microbiology and infectious disease2019
Meta-transcriptomic identification of hepatitis B virus in cerebrospinal fluid in patients with central nervous system disease.
Article in Diagnostic microbiology and infectious disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Case Report: A rare pediatric case of hepatitis B virus infection with acute disseminated encephalomyelitis/Guillain-Barré syndrome spectrum diseases.Frontiers in pediatrics · 2025Article
- The central nervous system is a potential reservoir and possible origin of drug resistance in hepatitis B infection.Journal of virus eradication · 2023Article
- Anti-CASPR2 myeloencephalitis with active replication of hepatitis B virus in the central nervous system: a case report.Acta neurologica Belgica · 2022Article
- Significance between air pollutants, meteorological factors, and COVID-19 infections: probable evidences in India.Environmental science and pollution research international · 2021Article
- Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990.One health (Amsterdam, Netherlands) · 2021Article
- Virome composition in marine fish revealed by meta-transcriptomics.Virus evolution · 2021Article
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Authors and funding
12 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the etiological basis of central nervous system (CNS) infections is inherently challenging, primarily due to the multi-etiological nature. Using RNA sequencing, we aimed to identify microbes present in cerebrospinal fluid (CSF) of two patients suffering CNS infection, previously diagnosed with Cryptococcus sp. and Streptococcus pneumoniae infection, respectively. After meta-transcriptomic analysis, and confirmation with real-time PCR, hepatitis B virus (HBV) was detected in the CSF of two patients diagnosed with CNS syndrome. Phylogenetic analysis of the partial HBV genomes from these patients showed that they belonged to genotypes B and C and clustered with other viruses of Asian origin. In countries with high levels of HBV endemicity, the virus is likely to be found in patients diagnosed with CNS infections, although whether it contributes to symptoms and pathology, or is simply a coincidental infection, is unknown and merits further investigation.
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