Evidence map›Paper›PMID 31451122›Full record

Trial reportPsychological medicine2020

Effect of behavior therapy for Tourette's disorder on psychiatric symptoms and functioning in adults.

Joseph F McGuire, Emily J Ricketts, Lawrence Scahill, Sabine Wilhelm, Douglas W Woods, John Piacentini, John T Walkup, Alan L Peterson

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Cognitive control processes in behavior therapy for youth with Tourette's disorder.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Trial
  3. Article
  4. Evidence-Based Behavior Therapy for Tourette Syndrome.The Psychiatric clinics of North America · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Tourette syndrome or PANDAS-a case report.Wiener medizinische Wochenschrift (1946) · 2021
    Article
  9. Article
  10. Tics and Tourette's syndrome.Drugs in context · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Joseph F McGuireDivision of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Emily J RickettsDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
Lawrence ScahillMarcus Autism Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Sabine WilhelmMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Douglas W WoodsDepartment of Psychology, Marquette University, Milwaukee, Wisconsin, USA.
John PiacentiniDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
John T WalkupLurie Children's Hospital, Chicago, Illinois, USA.
Alan L PetersonDepartment of Psychiatry, University of Texas Health Science at Center, San Antonio, Texas, USA.
University of California, Los Angeles · USJohns Hopkins Medicine · USLurie Children's Hospital · USMarcus (United States) · USMarquette University · USMassachusetts General Hospital · USSouth Texas Veterans Health Care System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Behavior Therapy for Adults with Tourette SyndromeR01MH069874 · NIMH · YALE UNIVERSITY · PI SCAHILL, LAWRENCE D. · 2005 to 2009
$1.2M
Investigating Circadian Rhythms in Youth with Persistent Tic DisordersK23MH113884 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RICKETTS, EMILY JULIA · 2017 to 2022
$992k
Behavior Therapy for Adults with Tourette SyndromeR01MH069877 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WILHELM, SABINE · 2005 to 2009
$918k
Behavior Therapy for Adults with Tourette SyndromeR01MH069875 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI PETERSON, ALAN L · 2005 to 2008
$719k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH113884NIMH NIH HHS R01 MH069874NIMH NIH HHS R01 MH069875NIMH NIH HHS R01 MH069877
6 · The paper itself

Abstract

backgroundAlthough behavior therapy reduces tic severity, it is unknown whether it improves co-occurring psychiatric symptoms and functional outcomes for adults with Tourette's disorder (TD). This information is essential for effective treatment planning. This study examined the effects of behavior therapy on psychiatric symptoms and functional outcomes in older adolescents and adults with TD.

methodA total of 122 individuals with TD or a chronic tic disorder participated in a clinical trial comparing behavior therapy to psychoeducation and supportive therapy. At baseline, posttreatment, and follow-up visits, participants completed assessments of tic severity, co-occurring symptoms (inattention, impulsiveness, hyperactivity, anger, anxiety, depression, obsessions, and compulsions), and psychosocial functioning. We compared changes in tic severity, psychiatric symptoms, and functional outcomes using repeated measure and one-way analysis of variance.

resultsAt posttreatment, participants receiving behavior therapy reported greater reductions in obsessions compared to participants in supportive therapy ($\eta _p^2 $ = 0.04, p = 0.04). Across treatments, a positive treatment response on the Clinical Global Impression of Improvement scale was associated with a reduced disruption in family life ($\eta _p^2 $ = 0.05, p = 0.02) and improved functioning in a parental role ($\eta _p^2 $ = 0.37, p = 0.02). Participants who responded positively to eight sessions of behavior therapy had an improvement in tic severity ($\eta _p^2 $ = 0.75, p < 0.001), inattention ($\eta _p^2 $ = 0.48, p < 0.02), and functioning ($\eta _p^2 $ = 0.39-0.42, p < 0.03-0.04) at the 6-month follow-up.

conclusionBehavior therapy has a therapeutic benefit for co-occurring obsessive symptoms in the short-term, and reduces tic severity and disability in adults with TD over time. Additional treatments may be necessary to address co-occurring symptoms and improve functional outcomes.

Indexed as

AdolescentAdultAgedBehavior TherapyCompulsive BehaviorFemaleHumansMaleMiddle AgedObsessive BehaviorPsychiatric Status Rating ScalesPsychosocial FunctioningTic DisordersTourette SyndromeTreatment OutcomeYoung AdultBehavior therapycomorbiditycomprehensive behavioral intervention for ticsdisabilityfunctioning.

Identifiers

PMID31451122
PMCPMC7190082
OpenAlexW2970614171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.