Evidence map›Paper›PMID 31450981›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Sin3a regulates the developmental progression through morula-to-blastocyst transition

Panpan Zhao, Shuang Li, Huanan Wang, Yanna Dang, Lefeng Wang, Tong Liu, Shaohua Wang, Xinhong Li, Kun Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

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  12. SIN3A Regulates Porcine Early Embryonic Development by ModulatingFrontiers in cell and developmental biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Panpan Zhao *Laboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Shuang Li *Laboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Huanan WangLaboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Yanna DangLaboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Lefeng WangLaboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Tong LiuLaboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Shaohua WangLaboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Xinhong LiAssisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Kun ZhangLaboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Sir Run Run Shaw Hospital · CNZhejiang University · CNShanghai Veterinary Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suppressor interacting 3a (Sin3a) is a scaffold component of the chromatin repressive complex Sin3/histone deacetylase (Hdac). Sin3a has been shown as a hub gene driving preimplantation development in both mice and humans. However, its precise functions during preimplantation development remain unclear. Here, we show that the embryos arrested at morula stage upon specific depletion of Sin3a in mouse early embryos. Given the reduced cell number in Sin3a-depleted embryos, blocked cell proliferation is observed, likely because of the increased level of Trp53 acetylation at lysine 379. Moreover, we found that Sin3a depletion reduces Cdx2 and Tir Na Nog (Nanog), suggesting a failure of the first cell fate decision. In addition, we noted a striking increase of genome-wide DNA methylation, likely attributed to the increased nuclear DNA methyltransferase 1 observed in Sin3a-depleted embryos. Notably, RNA sequencing analyses showed 717 genes are differentially expressed, and Gene Ontology analysis of down-regulated genes (

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsBlastocystCDX2 Transcription FactorFemaleHistone Deacetylase 1MiceMorulaNanog Homeobox ProteinRepressor ProteinsSin3 Histone Deacetylase and Corepressor ComplexTumor Suppressor Protein p53Cdx2 protein, mouseCDX2 Transcription FactorHdac1 protein, mouseHistone Deacetylase 1Nanog Homeobox ProteinNanog protein, mouseRepressor ProteinsSIN3A transcription factorSin3 Histone Deacetylase and Corepressor ComplexTrp53 protein, mouseTumor Suppressor Protein p53embryoHdac2pluripotencypreimplantationtrophectoderm

Identifiers

PMID31450981
PMCPMC6902730
OpenAlexW2970270322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.