Evidence map›Paper›PMID 31450846›Full record

ArticleInternational journal of molecular sciences2019

Aberrant Methylation Status of Tumour Suppressor Genes in Ovarian Cancer Tissue and Paired Plasma Samples.

Dana Dvorská, Dušan Braný, Bálint Nagy, Marián Grendár, Robert Poka, Beáta Soltész, Marianna Jagelková, Katarína Zelinová, Zora Lasabová, Pavol Zubor and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  14. Observational
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  17. Cell-Free Nucleic Acids.International journal of molecular sciences · 2019
    Article
  18. Ovarian Cancer Diagnosis and Prognosis Based on Cell-Free DNA Methylation.Cancer control : journal of the Moffitt Cancer Center
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Dana DvorskáDivision of Molecular Medicine, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Dušan BranýDivision of Molecular Medicine, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia. dusan.brany@uniba.sk.
Bálint NagyDepartment of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Marián GrendárBioinformatic Unit, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Robert PokaInstitute of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-1836-1579
Beáta SoltészDepartment of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Marianna JagelkováDepartment of Gynaecology and Obstetrics, Martin University Hospital, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Katarína ZelinováDepartment of Gynaecology and Obstetrics, Martin University Hospital, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Zora LasabováDivision of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Pavol ZuborDepartment of Gynaecology and Obstetrics, Martin University Hospital, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Zuzana DankováDivision of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Comenius University Bratislava · SKMartin University Hospital · SKUniversity of Debrecen · HU

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-14-0815European Regional Development Fund Molecular diagnosis of cervical cancer, ITMS: 26220220113Vedecká Grantová Agentúra MŠVVaŠ SR a SAV 1/0199/17
6 · The paper itself

Abstract

Ovarian cancer is a highly heterogeneous disease and its formation is affected by many epidemiological factors. It has typical lack of early signs and symptoms, and almost 70% of ovarian cancers are diagnosed in advanced stages. Robust, early and non-invasive ovarian cancer diagnosis will certainly be beneficial. Herein we analysed the regulatory sequence methylation profiles of the

Indexed as

Biomarkers, TumorDNA MethylationGenes, Tumor SuppressorAgedAged, 80 and overCpG IslandsFemaleGene Expression Regulation, NeoplasticHigh-Throughput Nucleotide SequencingHumansLiquid BiopsyMiddle AgedNeoplasm StagingOvarian NeoplasmsPromoter Regions, GeneticROC CurveBiomarkers, TumorCDH1cfDNAliquid biopsyovarian cancerPAX1PTENpyrosequencingRASSF1

Identifiers

PMID31450846
PMCPMC6747242
OpenAlexW2969586312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.