ArticleSensors (Basel, Switzerland)2019
Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices.
Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Coherent cavity coupling in O-band silicon photonic sensors for water environment detection.Scientific reports · 2026Article
- Surface and Interface Engineering in Integrated Photonic Sensors: Performance Trade-Offs, Stability, and Benchmarking.Micromachines · 2026Review
- Dispersion Engineering and Sensitivity Enhancement in Photonic Crystal Waveguide Sensors: Current Advances and Emerging Challenges.Sensors (Basel, Switzerland) · 2026Review
- Comprehensive Analysis of Advancement in Optical Biosensing Techniques for Early Detection of Cancerous Cells.Biosensors · 2025Review
- Sensing the Future-Frontiers in Biosensors: Exploring Classifications, Principles, and Recent Advances.ACS omega · 2024Review
- Monolithic Electronic-Biophotonic System-on-Chip for Label-Free Real-Time Molecular Sensing.IEEE journal of solid-state circuits · 2024Article
- Correction of 2Sensors (Basel, Switzerland) · 2024Article
- Plasmonic Biosensors: Review.Biology · 2022Review
- Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review.Sensors (Basel, Switzerland) · 2022Review
- Inverse-designed waveguide-based biosensor for high-sensitivity, single-frequency detection of biomolecules.Nanophotonics (Berlin, Germany) · 2022Article
- Construction of a mApple-D6A3-mediated biosensor for detection of heavy metal ions.AMB Express · 2020Article
- Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance.Diagnostics (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e., the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ∼ 10 - 8 RIU with a silicon nitride sensor operating at telecom wavelengths.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.