ArticleFoods (Basel, Switzerland)2019
Depicting the Non-Covalent Interaction of Whey Proteins with Galangin or Genistein Using the Multi-Spectroscopic Techniques and Molecular Docking.
Article in Foods (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 58 citations in OpenAlex.
- Structural and Antioxidant Comparison Between Native WPI and WPI-Resveratrol Non-Covalent Complex.Antioxidants (Basel, Switzerland) · 2026Article
- Morphological Characterization, Interaction Mechanisms, and Functional Properties of a Non-Covalent Whey Protein Isolate-Ellagic Acid Complex.Foods (Basel, Switzerland) · 2026Article
- Green development of whey protein-based complex system for the intestinal delivery of curcumin: Focus on formation mechanism, stability, andFood chemistry: X · 2025Article
- Exploring the noncovalent interaction between β-lactoglobulin and flavonoids under nonthermal process: Characterization, physicochemical properties, and potential for lycopene delivering.Food chemistry: X · 2025Article
- Inhibitory Mechanism of Camellianin A against α-Glucosidase: In Vitro and Molecular Simulation Studies.Foods (Basel, Switzerland) · 2024Article
- Encapsulation of zingerone by self-assembling peptides derived from fish viscera: Characterization, interaction and effects on colon epithelial cells.Food chemistry: X · 2024Article
- The Preparation and Characterization of Quinoa Protein Gels and Application in Eggless Bread.Foods (Basel, Switzerland) · 2024Article
- Molecular Interaction Mechanism and Preservative Effect of Lactone Sophorolipid and Lactoferrin/Foods (Basel, Switzerland) · 2023Article
- Bioactivity of Two Polyphenols Quercetin and Fisetin against Human Gastric Adenocarcinoma AGS Cells as Affected by Two Coexisting Proteins.Molecules (Basel, Switzerland) · 2022Article
- Digestive stability and transport ability changes of β-lactoglobulin-catechin complexes by M cell modelFrontiers in nutrition · 2022Article
- Amphiphilic small molecular mates match hydrophobic drugs to form nanoassemblies based on drug-mate strategy.Asian journal of pharmaceutical sciences · 2022Article
- Flavonoids-Macromolecules Interactions in Human Diseases with Focus on Alzheimer, Atherosclerosis and Cancer.Antioxidants (Basel, Switzerland) · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The non-covalent interactions between a commercial whey protein isolate (WPI) and two bioactive polyphenols galangin and genistein were studied at pH 6.8 via the multi-spectroscopic assays and molecular docking. When forming these WPI-polyphenol complexes, whey proteins had changed secondary structures while hydrophobic interaction was the major driving force. Detergent sodium dodecyl sulfate destroyed the hydrophobic interaction and thus decreased apparent binding constants of the WPI-polyphenol interactions. Urea led to hydrogen-bonds breakage and protein unfolding, and therefore increased apparent binding constants. Based on the measured apparent thermodynamic parameters like ΔH, ΔS, ΔG, and donor-acceptor distance, galangin with more planar stereochemical structure and random B-ring rotation showed higher affinity for WPI than genistein with location isomerism and twisted stereochemical structure. The molecular docking results disclosed that β-lactoglobulin of higher average hydrophobicity had better affinity for the two polyphenols than α-lactalbumin of lower average hydrophobicity while β-lactoglobulin possessed very similar binding sites to the two polyphenols. It is concluded that polyphenols might have different non-covalent interactions with food proteins, depending on the crucial polyphenol structures and protein hydrophobicity.
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