Evidence map›Paper›PMID 31450717›Full record

ArticleMarine drugs2019

Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues.

Maxim E Zhidkov, Polina A Smirnova, Oleg A Tryapkin, Alexey V Kantemirov, Yuliya V Khudyakova, Olesya S Malyarenko, Svetlana P Ermakova, Valeria P Grigorchuk, Moritz Kaune, Gunhild von Amsberg and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maxim E ZhidkovDepartment of organic chemistry and Laboratory of biologically active compounds, School of Natural Sciences, Far Eastern Federal University, 8 Sukhanov Str., Vladivostok 690950, Russia. mzhidkov@rambler.ru.
Polina A SmirnovaDepartment of organic chemistry and Laboratory of biologically active compounds, School of Natural Sciences, Far Eastern Federal University, 8 Sukhanov Str., Vladivostok 690950, Russia.
Oleg A TryapkinDepartment of organic chemistry and Laboratory of biologically active compounds, School of Natural Sciences, Far Eastern Federal University, 8 Sukhanov Str., Vladivostok 690950, Russia.
Alexey V KantemirovDepartment of organic chemistry and Laboratory of biologically active compounds, School of Natural Sciences, Far Eastern Federal University, 8 Sukhanov Str., Vladivostok 690950, Russia.
Yuliya V KhudyakovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, 159 Prospekt 100 Let Vladivostoku, Vladivostok 690022, Russia.
Olesya S MalyarenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, 159 Prospekt 100 Let Vladivostoku, Vladivostok 690022, Russia.
Svetlana P ErmakovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, 159 Prospekt 100 Let Vladivostoku, Vladivostok 690022, Russia.
Valeria P GrigorchukFederal Scientific Center of the East Asia Terrestrial Biodiversity (Institute of Biology and Soil Science), Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Let Vladivostoku, Vladivostok 690022, Russia.
Moritz KauneDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Gunhild von AmsbergDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Sergey A DyshlovoyDepartment of organic chemistry and Laboratory of biologically active compounds, School of Natural Sciences, Far Eastern Federal University, 8 Sukhanov Str., Vladivostok 690950, Russia.

Funding

FEFU Endowment Foundation D-349-17
6 · The paper itself

Abstract

A simple approach toward the synthesis of the marine sponge derived pigment fascaplysin was used to obtain the marine alkaloids 3-bromofascaplysin and 3,10-dibromofascaplysin. These compounds were used for first syntheses of the alkaloids 14-bromoreticulatate and 14-bromoreticulatine. Preliminary bioassays showed that 14-bromoreticulatine has a selective antibiotic (to

Indexed as

AlkaloidsAnimalsAnti-Bacterial AgentsAntineoplastic AgentsCarbolinesCell Line, TumorChemistry Techniques, SyntheticDrug Screening Assays, AntitumorHalogenationHumansIndolesIndolizinesMicrobial Sensitivity TestsPoriferaPseudomonas aeruginosaQuaternary Ammonium CompoundsAlkaloidsAnti-Bacterial AgentsAntineoplastic AgentsCarbolinesfascaplysineIndolesIndolizinesQuaternary Ammonium Compounds14-bromoreticulatine3,10-dibromofascaplysinbioactivitytotal synthesis

Identifiers

PMID31450717
PMCPMC6780422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.