Evidence map›Paper›PMID 31450601›Full record

ReviewJournal of clinical medicine2019

Prevalence of Non-Affective Psychoses in Individuals with Autism Spectrum Disorders: A Systematic Review.

Riccardo De Giorgi, Franco De Crescenzo, Gian Loreto D'Alò, Nicola Rizzo Pesci, Valeria Di Franco, Corrado Sandini, Marco Armando

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  19. A population-based survey of autistic traits in Kenyan adolescents and young adults.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Riccardo De GiorgiDepartment of Psychiatry, Medical Science Division, University of Oxford, Oxford OX3 7JX, UK.ORCID 0000-0001-5984-8696
Franco De CrescenzoDepartment of Psychiatry, Medical Science Division, University of Oxford, Oxford OX3 7JX, UK.ORCID 0000-0002-2478-7763
Gian Loreto D'AlòDepartment of Epidemiology, Lazio Regional Health Service, 00147 Rome, Italy.
Nicola Rizzo PesciDepartment of Clinical Neurosciences, University Vita-Salute San Raffaele, 20132 Milan, Italy.ORCID 0000-0003-3830-1485
Valeria Di FrancoDepartment of Anesthesiology and Intensive Care Medicine, Catholic University of The Sacred Heart, 00168 Rome, Italy.
Corrado SandiniDevelopmental Imaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva School of Medicine, CH-1211 Geneva, Switzerland.
Marco ArmandoDevelopmental Imaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva School of Medicine, CH-1211 Geneva, Switzerland. marco.armando@unige.ch.
Oxford Health NHS Foundation Trust · GBUniversity of Geneva · CHUniversità Cattolica del Sacro Cuore · ITUniversity of Rome Tor Vergata · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorders (ASD) and non-affective psychoses such as schizophrenia are commonly acknowledged as discrete entities. Previous research has revealed evidence of high comorbidity between these conditions, but their differential diagnosis proves difficult in routine clinical practice due to the similarities between core symptoms of each disorder. The prevalence of comorbid non-affective psychoses in individuals with ASD is uncertain, with studies reporting rates ranging from 0% to 61.5%. We therefore performed a systematic review and pooled analysis of the available studies reporting the prevalence of non-affective psychosis in ASD. Fourteen studies, including a total of 1708 participants, were included, with a weighted pooled prevalence assessed at 9.5% (95% CI 2.6 to 16.0). In view of significant heterogeneity amongst the studies, subgroup analyses were conducted. We observed higher prevalence of non-affective psychoses among ASD inpatients versus outpatients, when operationalised criteria were used, and in studies with smaller sample sizes, whereas the figures were comparable between children and adults with ASD. Our results suggest that future studies involving larger samples should implement both operationalized criteria and specific scales for the assessment of psychotic symptoms in individuals with ASD. A deeper understanding of both differential and comorbid features of ASD and non-affective psychosis will be required for the development of optimized clinical management protocols.

Indexed as

Autism spectrum disordersNon-affective psychosesPervasive developmental disordersSchizophrenia Spectrum DisordersSystematic review

Identifiers

PMID31450601
PMCPMC6780908
OpenAlexW2969441252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.