Evidence map›Paper›PMID 31450588›Full record

ArticleBiology2019

Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation.

Carlos Herrera-Úbeda, Marta Marín-Barba, Enrique Navas-Pérez, Jan Gravemeyer, Beatriz Albuixech-Crespo, Grant N Wheeler, Jordi Garcia-Fernàndez

Abstract read
In one paragraph

Article in Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Metamorphosis and lncRNAs: A Close Relationship.Genesis (New York, N.Y. : 2000) · 2026
    Review
  3. Article
  4. Article
  5. A conservedRNA biology · 2023
    Article
  6. Article
  7. Genomic and functional conservation of lncRNAs: lessons from flies.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Review
  8. Article
  9. There and Back Again: Hox Clusters Use Both DNA Strands.Journal of developmental biology · 2021
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carlos Herrera-ÚbedaDepartment of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-2334-9470
Marta Marín-BarbaSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TU, UK.
Enrique Navas-PérezDepartment of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.
Jan GravemeyerGerman Cancer Research Center, 69120 Heidelberg, Germany.
Beatriz Albuixech-CrespoDepartment of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.
Grant N WheelerSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TU, UK.ORCID 0000-0002-4335-8577
Jordi Garcia-FernàndezDepartment of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain. jordigarcia@ub.edu.ORCID 0000-0001-5677-5970

Funding

BIOADHESIVE MICROSPHERES FOR COLON CANCER THERAPYR43CA086152 · NCI · T AND B BIOCLONE, INC. · PI EGILMEZ, NEJAT K · 2000 to 2002
$419k
Biotechnology and Biological Sciences Research Council BB/H003525/1Ministerio de Ciencia, Innovación y Universidades BFU2017-86152-PSeventh Framework Programme REA Grant agreement number 607142
6 · The paper itself

Abstract

Homologous long non-coding RNAs (lncRNAs) are elusive to identify by sequence similarity due to their fast-evolutionary rate. Here we develop LincOFinder, a pipeline that finds conserved intergenic lncRNAs (lincRNAs) between distant related species by means of microsynteny analyses. Using this tool, we have identified 16 bona fide homologous lincRNAs between the amphioxus and human genomes. We characterized and compared in amphioxus and

Indexed as

amphioxusgenome_evolutionlncRNAssynteny

Identifiers

PMID31450588
PMCPMC6784235

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.