Evidence map›Paper›PMID 31450584›Full record

ReviewMolecules (Basel, Switzerland)2019

Seeing the Unseen of the Combination of Two Natural Resins, Frankincense and Myrrh: Changes in Chemical Constituents and Pharmacological Activities.

Bo Cao, Xi-Chuan Wei, Xiao-Rong Xu, Hai-Zhu Zhang, Chuan-Hong Luo, Bi Feng, Run-Chun Xu, Sheng-Yu Zhao, Xiao-Juan Du, Li Han and 1 more

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Trial
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  4. Review
  5. Qualitative phytochemical profiling, antioxidant activity, and development of a water-in-oil cream containing combined oil and water infusions of frankincense resin (Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026
    Article
  6. Assessing the Insecticidal Performance ofPlants (Basel, Switzerland) · 2025
    Article
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  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. An Evaluation of the Impact ofMolecules (Basel, Switzerland) · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bo CaoPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Xi-Chuan WeiPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Xiao-Rong XuPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Hai-Zhu ZhangDepartment of Pharmacy and Chemistry, Dali University, Dali 671000, China.
Chuan-Hong LuoPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Bi FengPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Run-Chun XuPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Sheng-Yu ZhaoPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China.
Xiao-Juan DuChengdu Yong Kang Pharmaceutical Co., Ltd., Chengdu 611130, China.
Li HanPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China. hanliyx@163.com.
Ding-Kun ZhangPharmacy College, Chengdu University of Traditional Chinese Medicine; Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China. zhangdingkun@cdutcm.edu.cn.

Funding

National Natural Science Foundation of China 81873232, 81274098
6 · The paper itself

Abstract

For the treatment of diseases, especially chronic diseases, traditional natural drugs have more effective therapeutic advantages because of their multi-target and multi-channel characteristics. Among many traditional natural medicines, resins frankincense and myrrh have been proven to be effective in the treatment of inflammation and cancer. In the West, frankincense and myrrh have been used as incense in religious and cultural ceremonies since ancient times; in traditional Chinese and Ayurvedic medicine, they are used mainly for the treatment of chronic diseases. The main chemical constituents of frankincense and myrrh are terpenoids and essential oils. Their common pharmacological effects are anti-inflammatory and anticancer. More interestingly, in traditional Chinese medicine, frankincense and myrrh have been combined as drug pairs in the same prescription for thousands of years, and their combination has a better therapeutic effect on diseases than a single drug. After the combination of frankincense and myrrh forms a blend, a series of changes take place in their chemical composition, such as the increase or decrease of the main active ingredients, the disappearance of native chemical components, and the emergence of new chemical components. At the same time, the pharmacological effects of the combination seem magically powerful, such as synergistic anti-inflammation, synergistic anticancer, synergistic analgesic, synergistic antibacterial, synergistic blood-activation, and so on. In this review, we summarize the latest research on the main chemical constituents and pharmacological activities of these two natural resins, along with chemical and pharmacological studies on the combination of the two.

Indexed as

Anti-Inflammatory AgentsAntineoplastic Agents, PhytogenicCommiphoraFrankincenseHumansMolecular StructurePhytochemicalsResins, PlantAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicFrankincensemyrrh resinPhytochemicalsResins, Plantanticanceranti-inflammatorycombinationfrankincensemyrrhpharmacological activityphytochemistrysynergyterpenoids

Identifiers

PMID31450584
PMCPMC6749531

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.