Evidence map›Paper›PMID 31450569›Full record

ArticleAntioxidants (Basel, Switzerland)2019

Increase of 4-Hydroxybenzoic, a Bioactive Phenolic Compound, after an Organic Intervention Diet.

Sara Hurtado-Barroso, Paola Quifer-Rada, María Marhuenda-Muñoz, Jose Fernando Rinaldi de Alvarenga, Anna Tresserra-Rimbau, Rosa M Lamuela-Raventós

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Bypass Treatments for Primary Coenzyme Q10 Deficiency: An Update.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Secondary Metabolites ofMolecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara Hurtado-BarrosoDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-9550-1788
Paola Quifer-RadaDepartment of Endocrinology & Nutrition, CIBER of Diabetes and Associated Metabolic Diseases, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
María Marhuenda-MuñozDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
Jose Fernando Rinaldi de AlvarengaDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
Anna Tresserra-RimbauConsorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
Rosa M Lamuela-RaventósDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain. lamuela@ub.edu.ORCID 0000-0002-1287-4560

Funding

HISTORICAL PROSPECTIVE--ORGANOCHLORINES/BREAST CANCERR03CA075329 · NCI · COLORADO STATE UNIVERSITY-FORT COLLINS · PI KEEFE, THOMAS J · 1997 to 1998
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Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición C03-01Departament d'Agricultura, Ramaderia, Pesca i Alimentació - Direcció General d'Agricultura i Ramaderia 53 05012 2016Generalitat de Catalunya SGR 2017Ministerio de Ciencia, Innovación y Universidades AGL2016-75329-R
6 · The paper itself

Abstract

Consumption of organic products is increasing yearly due to perceived health-promoting qualities. Several studies have shown higher amounts of phytochemicals such as polyphenols and carotenoids in foods produced by this type of agriculture than in conventional foods, but whether this increase has an impact on humans still needs to be assessed. A randomized, controlled and crossover study was carried out in nineteen healthy subjects aged 18-40 years, who all followed an organic and conventional healthy diet, both for a 4-week period. Analysis of biological samples revealed a significant increase on the excretion of 4-hydroxybenzoic acid (4-HBA), a phenolic metabolite with biological activity, after the organic intervention. However, no changes were observed in the other variables analyzed.

Indexed as

4-HBAcarotenescrossover studyhealthy diethumansinterventionmetalsmicrobiota metabolitesphenolic acid

Identifiers

PMID31450569
PMCPMC6769758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.