Evidence map›Paper›PMID 31450553›Full record

ArticleInternational journal of molecular sciences2019

Cortical Seizures in

Giovanna Testa, Francesco Olimpico, Laura Pancrazi, Ugo Borello, Antonino Cattaneo, Matteo Caleo, Mario Costa, Marco Mainardi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Rett and Rett-related disorders: Common mechanisms for shared symptoms?Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  7. Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Review
  9. Review
  10. Extremely Low Forces Induce Extreme Axon Growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  11. The Role of FoxG1 in the Inner Ear.Frontiers in cell and developmental biology · 2020
    Review
  12. Synaptic Pruning by Microglia in Epilepsy.Journal of clinical medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giovanna TestaLaboratory of Biology "Bio@SNS", Scuola Normale Superiore, 56126 Pisa, Italy.
Francesco OlimpicoInstitute of Neuroscience, Italian National Research Council (IN-CNR), 56124 Pisa, Italy.
Laura PancraziInstitute of Neuroscience, Italian National Research Council (IN-CNR), 56124 Pisa, Italy.
Ugo BorelloUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.ORCID 0000-0001-9812-579X
Antonino CattaneoLaboratory of Biology "Bio@SNS", Scuola Normale Superiore, 56126 Pisa, Italy.
Matteo CaleoInstitute of Neuroscience, Italian National Research Council (IN-CNR), 56124 Pisa, Italy.ORCID 0000-0002-4333-6378
Mario CostaInstitute of Neuroscience, Italian National Research Council (IN-CNR), 56124 Pisa, Italy. Mario.costa@in.cnr.it.
Marco MainardiLaboratory of Biology "Bio@SNS", Scuola Normale Superiore, 56126 Pisa, Italy. marco.mainardi@sns.it.

Funding

Associazione Italiana per la Ricerca sul Cancro IG 2016-18925Fondazione Pisa NanoBioMarker 2016
6 · The paper itself

Abstract

The correct morphofunctional shaping of the cerebral cortex requires a continuous interaction between intrinsic (genes/molecules expressed within the tissue) and extrinsic (e.g., neural activity) factors at all developmental stages. Forkhead Box G1 (FOXG1) is an evolutionarily conserved transcription factor, essential for the cerebral cortex patterning and layering. FOXG1-related disorders, including the congenital form of Rett syndrome, can be caused by deletions, intragenic mutations or duplications. These genetic alterations are associated with a complex phenotypic spectrum, spanning from intellectual disability, microcephaly, to autistic features, and epilepsy. We investigated the functional correlates of dysregulated gene expression by performing electrophysiological assays on

Indexed as

Synaptic TransmissionAnimalsCerebral CortexDisease Models, AnimalDisease SusceptibilityEpilepsyForkhead Transcription FactorsGene Expression RegulationGene Regulatory NetworksMiceMice, KnockoutNerve Tissue ProteinsPhenotypeProto-Oncogene Proteins c-aktRibosomal Protein S6 KinasesSeizuresForkhead Transcription FactorsFoxg1 protein, mouseNerve Tissue ProteinsProto-Oncogene Proteins c-aktRibosomal Protein S6 KinaseselectrophysiologyepilepsyRett syndrome

Identifiers

PMID31450553
PMCPMC6747530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.