Observational studyPediatric research2020
Quality assessment and response to less invasive surfactant administration (LISA) without sedation.
Observational study in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Safety of Less Invasive Surfactant Administration in Preterm Infants: A Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- Sedation for less invasive surfactant administration in preterm infants: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Trial
- Low invasive surfactant administration by videolaringoscopy: a feasibility study.Italian journal of pediatrics · 2025Article
- Procedural success and safety of a standardized less invasive surfactant administration protocol using fentanyl premedication and video laryngoscopy in preterm infants <32 weeks' gestation.Frontiers in pediatrics · 2025Article
- Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies.Antioxidants (Basel, Switzerland) · 2023Review
- Assessment of Comfort during Less Invasive Surfactant Administration in Very Preterm Infants: A Multicenter Study.Neonatology · 2023Observational
- Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial.Clinical and experimental pediatrics · 2022Article
- Premedication before laryngoscopy in neonates: Evidence-based statement from the French society of neonatology (SFN).Frontiers in pediatrics · 2022Review
- Premedication for nonemergent intubations linked to fewer adverse events.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- New techniques, new challenges-The dilemma of pain management for less invasive surfactant administration?Paediatric & neonatal pain · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough sedative premedication for endotracheal intubation is considered standard of care, less invasive surfactant administration (LISA) is often performed without sedative premedication. The aim of this study was to assess success rates, technical quality and vital parameters in LISA without sedative premedication.
methodsProspective observational study in 86 neonates <32 weeks' gestation. LISA was performed according to a standardized protocol without use of sedative premedication. Outcome measures were success rates of LISA attempts, reasons for failure and quality of technical conditions. In 37 neonates, heart rate and oxygen saturation levels from 20 min before until 30 min after start of LISA were collected.
resultsIn 48% of LISAs the first attempt failed and in 34% quality of technical conditions was inadequate. The success rate was significantly correlated with quality of technical conditions and experience of the performer. Desaturations <80% occurred in 54% of patients while bradycardia <80/min did not occur.
conclusionThis study shows a relatively low success rate of the first attempt of LISA, frequent inadequacy of technical quality and frequent oxygen desaturations. These effects may be improved by the use of sedative premedication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.