Evidence map›Paper›PMID 31450025›Full record

ArticleInfant behavior & development2019

Exploring cortical activation and connectivity in infants with and without familial risk for autism during naturalistic social interactions: A preliminary study.

A N Bhat, N M McDonald, J E Eilbott, K A Pelphrey

Abstract read
In one paragraph

Article in Infant behavior & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Towards imaging the infant brain at play.Communicative & integrative biology · 2023
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  16. Looking Back at the Next 40 Years of ASD Neuroscience Research.Journal of autism and developmental disorders · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A N BhatDepartment of Physical Therapy, University of Delaware, 540 S College Ave., Newark, DE, USA; Department of Psychological & Brain Sciences, University of Delaware, 320 McKinly Lab, Newark, DE, USA; Biomechanics & Movement Science Program, University of Delaware, 540 S College Ave., Newark, DE, USA. Electronic address: abhat@udel.edu.
N M McDonaldDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, 760 Westwood Plaza, Los Angeles, CA, USA.
J E EilbottYale Child Study Center, Yale University, New Haven, CT, USA.
K A PelphreyDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Megan M Wenner · 2013 to 2026
$60.5M
ETG-4000 Optical Topography SystemS10OD021534 · OD · UNIVERSITY OF DELAWARE · PI BHAT, ANJANA NARAYAN · 2016 to 2016
$528k
Infant Social Development: From Brain to BehaviorF32MH108283 · NIMH · YALE UNIVERSITY · PI MCDONALD, NICOLE M · 2015 to 2018
$173k
NIGMS NIH HHS U54 GM104941NIH HHS S10 OD021534NIMH NIH HHS F32 MH108283
6 · The paper itself

Abstract

Behavioral signs of Autism Spectrum Disorder (ASD) are typically observable by the second year of life and a reliable diagnosis of ASD is possible by 2 to 3 years of age. Studying infants with familial risk for ASD allows for the investigation of early signs of ASD risk within the first year. Brain abnormalities such as hyper-connectivity within the first year may precede the overt signs of ASD that emerge later in life. In this preliminary study, we use functional near-infrared spectroscopy (fNIRS), an infant-friendly neuroimaging tool that is relatively robust against motion artifacts, to examine functional activation and connectivity during naturalistic social interactions in 9 high-risk (HR; older sibling with ASD) and 6 low-risk (LR; no family history of ASD) infants from 6 to 9 months of age. We obtained two 30-second baseline periods and a 5-minute social interaction period. HR infants showed reduced right and left-hemispheric activation compared to LR infants based on oxy (HbO

Indexed as

Interpersonal RelationsAutism Spectrum DisorderCerebral CortexFemaleGenetic Predisposition to DiseaseHumansInfantMaleNerve NetParent-Child RelationsProof of Concept StudyRisk FactorsSiblingsSpectroscopy, Near-InfraredAutism spectrum disorderCortical activationfNIRSFunctional connectivityInfantsSocial interaction

Identifiers

PMID31450025
PMCPMC6875633

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.