ArticleBiological psychology2019
Fear conditioning and extinction in anxious youth, offspring at-risk for anxiety and healthy comparisons: An fMRI study.
Article in Biological psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Trauma From the Eye of the Beholder: Reporter Discordance in Children's Trauma, Psychopathology, and Neurobiology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Neurobiological Signatures of Dyadic Transmission of Fear Extinction in Adolescent Trauma Exposure and Posttraumatic Stress.Biological psychiatry global open science · 2026Article
- Aversively conditioned context enhances visual size illusion via stimulus-specific neural networks.iScience · 2025Article
- Fear extinction retention in children, adolescents, and adults.Developmental cognitive neuroscience · 2025Article
- Extinction Learning Across Development: Neurodevelopmental Changes and Implications for Pediatric Anxiety Disorders.Current topics in behavioral neurosciences · 2023Article
- Understanding clinical fear and anxiety through the lens of human fear conditioning.Nature reviews psychology · 2023Review
- Getting Better with Age? A Review of Psychophysiological Studies of Fear Extinction Learning Across Development.Current topics in behavioral neurosciences · 2023Review
- Dysregulation of threat neurociruitry during fear extinction: the role of anhedonia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Safety learning during development: Implications for development of psychopathology.Behavioural brain research · 2021Review
- Pavlovian Learning Processes in Pediatric Anxiety Disorders: A Critical Review.Biological psychiatry · 2021Review
- Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders - A preliminary study.Behavioural brain research · 2021Article
- Altered functional activations of prefrontal brain areas during emotional processing of fear in Inuit adolescents exposed to environmental contaminants.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dysfunctions in fronto-amygdala circuitry have been linked to anxiety. Questions remain regarding the impact of familial-risk and ongoing anxiety on such circuitry function, especially in youth. Using fMRI fear conditioning and extinction paradigms, we examined these relationships in 10-17 year-olds: 22 youth with an anxiety disorder, 22 healthy youth born to parents with past or current anxiety disorders (at risk), and 32 healthy comparisons. Skin conductance responses and subjective fear ratings were also assessed. During conditioning, healthy comparisons showed differential activation (CS + >CS-) in regions of the fronto-amygdala circuitry. In comparison, the at-risk group showed greater activation to the safety cue (CS - >CS+) in the amygdala and dorsolateral prefrontal cortex. Failure to show differential fear conditioning in the fronto-amygdala circuitry and impairment in extinction learning was specific to anxious youth. These findings expand our ability to track anxiety-related alterations and potential resilience markers to anxiety.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.