Evidence map›Paper›PMID 31449707›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Modification of Enzyme Activity by Vibrational Strong Coupling of Water.

Robrecht M A Vergauwe, Anoop Thomas, Kalaivanan Nagarajan, Atef Shalabney, Jino George, Thibault Chervy, Marcus Seidel, Eloïse Devaux, Vladimir Torbeev, Thomas W Ebbesen

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 228 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Changes in Water Dynamics by Osmolytes Regulate Enzyme Activity.The journal of physical chemistry. B · 2026
    Article
  8. Cluster Formation and Phase Transitions Induced by Vibrational Strong Coupling.Angewandte Chemie (International ed. in English) · 2026
    Article
  9. The Diels-Alder Reaction as a Mechanistic Probe for Vibrational Strong Coupling.Angewandte Chemie (International ed. in English) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
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  18. Article
  19. Do Molecular Geometries Change Under Vibrational Strong Coupling?The journal of physical chemistry letters · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 4 countries.

Robrecht M A VergauweUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0003-0221-5446
Anoop ThomasUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0001-8702-4934
Kalaivanan NagarajanUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0002-2933-9951
Atef ShalabneyBraude College, Snunit Street 51, Karmiel, 2161002, Israel.ORCID 0000-0003-3379-5252
Jino GeorgeUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0002-3558-6553
Thibault ChervyUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0002-5287-7002
Marcus SeidelUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0002-6246-1772
Eloïse DevauxUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0003-3220-7156
Vladimir TorbeevUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0002-7865-1044
Thomas W EbbesenUniversity of Strasbourg, CNRS, ISIS & icFRC, 8 allée Gaspard Monge, 67000, Strasbourg, France.ORCID 0000-0002-3999-1636
Centre National de la Recherche Scientifique · FRBraude College of Engineering Karmiel · IL

Funding

Agence Nationale de la Recherche ANR-10-EQPX-52-01Agence Nationale de la Recherche ANR-10-IDEX-0002-02Agence Nationale de la Recherche ANR-10-LABX- 0026 CSCEuropean Research Council 788482
6 · The paper itself

Abstract

Vibrational strong coupling (VSC) has recently emerged as a completely new tool for influencing chemical reactivity. It harnesses electromagnetic vacuum fluctuations through the creation of hybrid states of light and matter, called polaritonic states, in an optical cavity resonant to a molecular absorption band. Here, we investigate the effect of vibrational strong coupling of water on the enzymatic activity of pepsin, where a water molecule is directly involved in the enzyme's chemical mechanism. We observe an approximately 4.5-fold decrease of the apparent second-order rate constant k

Indexed as

enzymeslight-matter strong couplingoptical cavitiesvibrational spectroscopywater

Identifiers

PMID31449707
PMCPMC6856831
OpenAlexW2970795575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.