ArticlePloS one2019
Multi-objective optimisation of material properties and strut geometry for poly(L-lactic acid) coronary stents using response surface methodology.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- State-of-the-Art Review on Finite Element Analysis Applied to Ultrathin-Strut Drug-Eluting Stents: Examining the Present and Looking Ahead to the Future.Bioengineering (Basel, Switzerland) · 2026Review
- How plaque morphology and stenosis severity govern stent-artery interaction and deployment outcomes: a computational study.Medical & biological engineering & computing · 2026Article
- Computational modeling of stent failure during crimping and deployment in coronary arteries.Biomechanics and modeling in mechanobiology · 2026Article
- Numerical Evaluation of a Zero Poisson's Ratio Structure in µ-3D-Printed Self-Expanding Nitinol Stents.Micromachines · 2026Article
- Recent Patents of Stent Grafts for Intravascular Aortic Repair.Recent patents on biotechnology · 2026Review
- Article
- Influence of Stent Structure on Mechanical and Degradation Properties of Poly (Lactic Acid) Vascular Stent.Journal of functional biomaterials · 2025Article
- Advancements in Coronary Bifurcation Stenting Techniques: Insights From Computational and Bench Testing Studies.International journal for numerical methods in biomedical engineering · 2025Review
- Investigating the Equivalent Plastic Strain in a Variable Ring Length and Strut Width Thin-Strut Bioresorbable Scaffold.Cardiovascular engineering and technology · 2022Article
- Two-stage degradation and novel functional endothelium characteristics of a 3-D printed bioresorbable scaffold.Bioactive materials · 2022Article
- 3D Printing of Polymeric Bioresorbable Stents: A Strategy to Improve Both Cellular Compatibility and Mechanical Properties.Polymers · 2022Review
- Structure design method of new balanced vibration reduction gear for the three cylinder engine.PloS one · 2022Article
- Design optimization of a cardiovascular stent with application to a balloon expandable prosthetic heart valve.Materials & design · 2021Article
- Design of Self-Expanding Auxetic Stents Using Topology Optimization.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary stents for treating atherosclerosis are traditionally manufactured from metallic alloys. However, metal stents permanently reside in the body and may trigger undesirable immunological responses. Bioresorbable polymer stents can provide a temporary scaffold that resorbs once the artery heals but are mechanically inferior, requiring thicker struts for equivalent radial support, which may increase thrombosis risk. This study addresses the challenge of designing mechanically effective but sufficiently thin poly(L-lactic acid) stents through a computational approach that optimises material properties and stent geometry. Forty parametric stent designs were generated: cross-sectional area (post-dilation), foreshortening, stent-to-artery ratio and radial collapse pressure were evaluated computationally using finite element analysis. Response surface methodology was used to identify performance trade-offs by formulating relationships between design parameters and response variables. Multi-objective optimisation was used to identify suitable stent designs from approximated Pareto fronts and an optimal design is proposed that offers comparable performance to designs in clinical practice. In summary, a computational framework has been developed that has potential application in the design of high stiffness, thin strut polymeric stents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.