ArticleEnvironmental health perspectives2019
Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study.
Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Sex Differences in Cardiovascular Risk Associated With Long-Term PMFrontiers in public health · 2022Pooled it
- Ambient fine particulate matter of diameter ≤ 2.5 μm and risk of hemorrhagic stroke: a systemic review and meta-analysis of cohort studies.Environmental science and pollution research international · 2021Pooled it
- Long-Term PMJournal of the American Heart Association · 2021Pooled it
- Association between fine particulate matter and atrial fibrillation in implantable cardioverter defibrillator patients: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020Pooled it
- Article
- Short-term effects of ambient air pollutants on neurological hospital admissions: a time-series analysis in a northern Chinese city.BMC public health · 2026Article
- Impact of air pollution on exacerbations of respiratory and cardiovascular diseases for the intensivist: a narrative review.Intensive care medicine experimental · 2026Review
- Ethnic inequalities in ischemic stroke occurrence are partly mediated by air pollution: a Dutch nationwide follow-up analysis.BMC public health · 2026Article
- Neighborhood economic and demographic landscape as predictors of 90-day outcomes post-stroke hospitalization.Frontiers in stroke · 2026Article
- The Effects of Air Pollution on Atrial Fibrillation: A Systematic Review.Environmental health insights · 2026Review
- Cardiac electrophysiological responses to traffic pollution in adults with or without chronic cardiopulmonary diseases.Environment international · 2025Article
- Global, regional and national burden of stroke and subtypes burden in women of reproductive age: insights based on Global Burden of Disease 2021.BMC public health · 2025Article
- Long-term exposure to air pollution and incidence risk of various arrhythmias: A prospective cohort study.Eco-Environment & Health · 2024Article
- Cardiometabolic Health Effects of Air Pollution, Noise, Green Space, and Socioeconomic Status: The HERMES Study.Research report (Health Effects Institute) · 2024Article
- Global, regional, and national impact of air pollution on stroke burden: changing landscape from 1990 to 2021.BMC public health · 2024Article
- Association between long-term exposure to low ambient PMEnvironment international · 2024Article
- Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study.European journal of neurology · 2024Article
- Air Pollutants and Mortality Risk in Patients with Aortic Dissection: Evidence from a Clinical Cohort, Single-Cell Sequencing, and Proteomics.Environmental science & technology · 2024Article
- Pathogenesis of PMEpigenomes · 2024Review
- Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough growing evidence links air pollution to stroke incidence, less is known about the effect of air pollution on atrial fibrillation (AF), an important risk factor for stroke.
objectivesWe assessed the associations between air pollution and incidence of AF and stroke. We also sought to characterize the shape of pollutant-disease relationships.
methodsThe population-based cohort comprised 5,071,956 Ontario residents, age 35–85 y and without the diagnoses of both outcomes on 1 April 2001 and was followed up until 31 March 2015. AF and stroke cases were ascertained using health administrative databases with validated algorithms. Based on annual residential postal codes, we assigned 5-y running average concentrations of fine particulate matter ([Formula: see text]), nitrogen dioxide ([Formula: see text]), and ozone ([Formula: see text]) from satellite-derived data, a land-use regression model, and a fusion-based method, respectively, as well as redox-weighted averages of [Formula: see text] and [Formula: see text] ([Formula: see text]) for each year. Using Cox proportional hazards models, we estimated the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of AF and stroke with each of these pollutants, adjusting for individual- and neighborhood-level variables. We used newly developed nonlinear risk models to characterize the shape of pollutant–disease relationships.
resultsBetween 2001 and 2015, we identified 313,157 incident cases of AF and 122,545 cases of stroke. Interquartile range increments of [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text] were associated with increases in the incidence of AF [HRs (95% CIs): 1.03 (1.01, 1.04), 1.02 (1.01, 1.03), 1.01 (1.00, 1.02), and 1.01 (1.01, 1.02), respectively] and the incidence of stroke [HRs (95% CIs): 1.05 (1.03, 1.07), 1.04 (1.01, 1.06), 1.05 (1.03, 1.06), and 1.05 (1.04, 1.06), respectively]. Associations of similar magnitude were found in various sensitivity analyses. Furthermore, we found a near-linear association for stroke with [Formula: see text], whereas [Formula: see text], [Formula: see text]-, and [Formula: see text] relationships exhibited sublinear shapes.
conclusionsAir pollution was associated with stroke and AF onset, even at very low concentrations. https://doi.org/10.1289/EHP4883.
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