ArticleIEEE transactions on bio-medical engineering2020
Selective Nerve Cuff Stimulation Strategies for Prolonging Muscle Output.
Article in IEEE transactions on bio-medical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A methodological framework for the efficient characterization of peripheral nerve stimulation parameters.Journal of neural engineering · 2025Trial
- Selective activation of nerve fiber subpopulations with intrafascicular stimulation.Journal of neural engineering · 2026Article
- Selective Activation of Nerve Fiber Subpopulations with Intrafascicular Stimulation.bioRxiv : the preprint server for biology · 2026Article
- A myoneural actuator with engineered biophysics for implantable biohybrid systems.Nature communications · 2026Article
- Multi-Channel Microscale Nerve Cuffs for Spatially Selective Neuromodulation.Micromachines · 2024Article
- A Wirelessly Powered 4-Channel Neurostimulator for Reconstructing Walking Trajectory.Sensors (Basel, Switzerland) · 2022Article
- Selective neural stimulation methods improve cycling exercise performance after spinal cord injury: a case series.Journal of neuroengineering and rehabilitation · 2021Article
- Sum of phase-shifted sinusoids stimulation prolongs paralyzed muscle output.Journal of neuroengineering and rehabilitation · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neural stimulation systems are often limited by rapid muscle fatigue. Selective nerve cuff electrodes can target independent yet synergistic motor unit pools (MUPs), which can be used in duty-cycle reducing stimulation paradigms to prolong joint moment output.
objectiveThis study investigates waveform parameters within moment-prolonging paradigms and determines strategies for their optimal implementation.
methodsComposite flat-interface nerve cuff electrodes (C-FINEs) were chronically implanted on feline proximal sciatic nerves. Cyclic stimulation tests determined effects of stimulation period and duty cycle in different MUP types. Ideal parameters were then used in duty-cycle reducing carousel stimulation. Time to 50% reduction in moment (T50), moment overshoot, and moment ripple were determined for constant, open-loop carousel, and moment feedback-controlled closed-loop carousel stimulation.
resultsA stimulation period of 1 s best maintained joint moment for all MUPs. Low (25%) duty cycles consistently improved joint moment maintenance, though allowable duty cycle varied among MUPs by gross muscle and fiber type. Both open- and closed-loop carousel stimulation significantly increased T50 over constant stimulation. Closed-loop carousel significantly decreased moment overshoot over the other conditions, and significantly decreased moment ripple compared with open-loop stimulation.
conclusionSelectivity-enabled carousel stimulation prolongs joint moment over conventional constant stimulation. Appropriate waveform parameters can be quickly determined for individual MUPs and stimulation can be controlled for additional performance improvements with this paradigm. SIGNIFICANCE: Providing prolonged, stable joint moment and muscle output to recipients of motor neuroprostheses will improve clinical outcomes, increase independence, and positively impact quality of life.
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