Evidence map›Paper›PMID 31448942›Full record

ArticleNeuropsychology2020

Linking depressive symptoms and cognitive functioning: The mediating role of leisure activity.

Neika Sharifian, Yian Gu, Jennifer J Manly, Nicole Schupf, Richard Mayeux, Adam M Brickman, Laura B Zahodne

Abstract read
In one paragraph

Article in Neuropsychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  10. Depressive Symptoms, Leisure Activity Engagement, and Global Cognition in Non-Hispanic Black and White Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Neika SharifianDepartment of Psychology.
Yian GuDepartment of Neurology, The Taub Institute for Research on Alzheimer's Disease.
Jennifer J ManlyDepartment of Neurology, The Taub Institute for Research on Alzheimer's Disease.
Nicole SchupfDepartment of Neurology, The Taub Institute for Research on Alzheimer's Disease.
Richard MayeuxDepartment of Neurology, The Taub Institute for Research on Alzheimer's Disease.
Adam M BrickmanDepartment of Neurology, The Taub Institute for Research on Alzheimer's Disease.
Laura B ZahodneDepartment of Psychology.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LUCHSINGER, JOSE ALEJANDRO · 1989 to 2008
$21.7M
Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging ProjectRF1AG066107 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2022
$11.4M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Resilience Mechanisms Underlying Racial/Ethnic Disparities in Alzheimer’s DiseaseR01AG054520 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, ZAHODNE, LAURA B · 2017 to 2021
$5.8M
The role of inflammation in the association between diet and Alzheimer's diseaseR01AG059013 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GU, YIAN · 2019 to 2023
$3.7M
Psychosocial Protective Factors in Cognitive and Brain AgingR00AG047963 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZAHODNE, LAURA B · 2016 to 2018
$746k
National Institutes of Health; National Center for Advancing Translational SciencesNational Institutes on AgingNCATS NIH HHS UL1 TR001873NIA NIH HHS P01 AG007232NIA NIH HHS R00 AG047963NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG054520NIA NIH HHS RF1 AG054023NIA NIH HHS RF1 AG066107
6 · The paper itself

Abstract

objectivesGreater depressive symptoms are associated with cognitive decline in older adulthood, but it is not clear what underlying factors drive this association. One behavioral pathway through which depressive symptoms may negatively influence cognitive functioning is through activity engagement. Prior research has independently linked greater depressive symptoms to both lower leisure and physical activity and independently linked both lower leisure and physical activity to lower cognition. Therefore, depressive symptoms may negatively influence cognition by reducing engagement in beneficial leisure and/or physical activities that help to maintain cognition.

methodsThe current study examined associations between depressive symptoms, leisure activity, physical activity, and global cognitive functioning using longitudinal data from the Washington Heights-Inwood Columbia Aging Project (n = 5,458 older adults). A multilevel structural equation model estimated the between-person and within-person effects of depressive symptoms on global cognition through leisure and physical activity.

resultsLeisure activity, but not physical activity, mediated the association between depressive symptoms and global cognition between- and within-persons. When individuals reported high depressive symptoms, they also reported fewer leisure activities, which was associated with lower global cognition.

conclusionThese findings highlight behavioral pathways through which depressive symptoms may negatively influence cognitive functioning. Findings support the view that perhaps depressive symptoms act as a risk factor for cognitive impairment by reducing leisure activity engagement. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Indexed as

CognitionAgedAged, 80 and overAge FactorsAgingCognitive DysfunctionDepressionExerciseFemaleHumansLeisure ActivitiesLongitudinal StudiesMaleNeuropsychological Tests

Identifiers

PMID31448942
PMCPMC6940545

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.