ArticlePhysiological reports2019
Serum testosterone acts as a prognostic indicator in polycystic ovary syndrome-associated kidney injury.
Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Prediction of cardiovascular disease risk in women and individuals with polycystic ovary syndrome using the American Heart Association PREVENT model: A long-term population-based cohort study.American journal of preventive cardiology · 2026Article
- Androgen Receptor PROTAC ARV-110 Ameliorates Metabolic Complications in a Mouse Model of Polycystic Ovary Syndrome.Endocrinology · 2025Article
- Advancement in early diagnosis of polycystic ovary syndrome: biomarker-driven innovative diagnostic sensor.Mikrochimica acta · 2025Review
- Link between iron-mediated lipid peroxidation and polycystic ovary syndrome (PCOS): exploring the genes underlying iron regulatory mechanism.Journal of ovarian research · 2025Article
- Obesity is associated with lower levels of negative emotions in polycystic ovary syndrome in clinical and animal studies.Annals of medicine · 2024Article
- Thyroid function and polycystic ovary syndrome: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Biomarkers in Polycystic Ovary Syndrome.Current opinion in physiology · 2023Article
- Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling.Acta pharmacologica Sinica · 2023Article
- Assessment of hepatoprotective, nephroprotective efficacy, and antioxidative potential ofFood science & nutrition · 2023Article
- Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model.Iranian journal of medical sciences · 2023Article
- Identification and immune features of cuproptosis-related molecular clusters in polycystic ovary syndrome.Scientific reports · 2023Article
- Causal relationship between polycystic ovary syndrome and chronic kidney disease: A Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Obesity-associated cardiometabolic complications in polycystic ovary syndrome: The potential role of sodium-glucose cotransporter-2 inhibitors.Frontiers in endocrinology · 2023Review
- Suggesting disease associations for overlooked metabolites using literature from metabolic neighbors.GigaScience · 2022Article
- The Protective Effects of Trans-Anethole against Polycystic Ovary Syndrome Induced Histopathological and Metabolic Changes in Rat.International journal of fertility & sterility · 2022Article
- Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition.Biology of sex differences · 2022Article
- Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome.Reproductive biology and endocrinology : RB&E · 2022Article
- Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease.Frontiers in endocrinology · 2022Article
- Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome.Saudi journal of biological sciences · 2021Article
- Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19.International journal of molecular sciences · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic ovary syndrome (PCOS) is closely related with the onset and development of metabolic abnormalities. However, the correlation between PCOS and kidney injury has not been clarified, and the underlying mechanism remains unknown. Herein, we performed a prospective survey in 55 PCOS and 69 healthy participants. Furthermore, the correlation analyses between serum testosterone and renal functional manifestations of patients and healthy subjects, including urinary albumin to creatinine ratio (UACR), urinary κ-light chains (KapU), urinary λ-light chains (LamU), urinary α1-microglobulin (α1-MU), and urinary β2-microglobulin (β2-MU), were analyzed. Compared with that in normal subjects, the levels of serum testosterone and UACR were significantly higher in PCOS patients. Serum testosterone is significantly correlated with the disease severity of PCOS. Although urinary excretions of KapU, LamU, α1-MU, and β2-MU did not increase in PCOS patients, they had a significantly positive correlation with the extent of serum testosterone in PCOS patients. IN vitro, primary cultured human ovary granulosa cells (GCs) were isolated from the follicular fluid (FF) extracting from PCOS patients and controls. FF, especially which extracted from PCOS patients with a high expression of serum testosterone, significantly induced cell apoptosis and inflammation in human GCs. To examine the communication between PCOS and kidney injury, a human proximal tubular epithelial cell line (HKC-8) was cultured and administered FF. Interestingly, FF from PCOS patients with a higher level of serum testosterone induced fibrotic lesions in HKC-8 cells. These data suggest serum testosterone plays a critical role in PCOS and PCOS-associated kidney injury. Serum testosterone may serve as a promising indicator for kidney fibrotic injury outcomes in PCOS patients.
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