ArticleBrain and behavior2019
Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Context-dependent interaction between oxytocin gene polymorphisms and alcohol dependence in modulating negative emotions during acute alcohol withdrawal in adult males.Frontiers in psychiatry · 2026Article
- Assessment of Aggression and Anger Levels in Athletes: A Study on Gene Polymorphisms in Forensic Science.Genes · 2025Article
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- Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis.Genes · 2023Article
- MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension.Journal of aging research · 2023Article
- Unraveling the Contribution of Serotonergic Polymorphisms, Prefrontal Alpha Asymmetry, and Individual Alpha Peak Frequency to the Emotion-Related Impulsivity Endophenotype.Molecular neurobiology · 2022Article
- Association of Polymorphism within the Putative miRNA Target Site in the 3'UTR Region of theInternational journal of environmental research and public health · 2022Article
- Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Spirituality and religiousness as predictors of life satisfaction among Peruvian citizens during the COVID-19 pandemic.Heliyon · 2021Article
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- Depressive Symptoms among Middle-Aged Women-Understanding the Cause.Brain sciences · 2020Article
- Predicting Perceived Stress Related to the Covid-19 Outbreak through Stable Psychological Traits and Machine Learning Models.Journal of clinical medicine · 2020Article
- Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.Frontiers in psychiatry · 2020Review
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- Do boys with MAOA_LPR*2R allele present cognitive and learning impairments?Dementia & neuropsychologiaArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroticism is associated with low emotional stability, and it is characterized by a tendency to perceive ordinary situations as threatening and difficult to manage. This personality trait has been associated with psychological distress and predicts some mental disorders. Previous studies have shown that women tend to be more neurotic than men and, in general, females have also a higher incidence of anxious and depressive disorders.
methodsWe analyzed in a sample of 99 female university students (from 18 to 26 years old) if emotional stability, measured using the Big Five Questionnaire, was linked to polymorphic variants in candidate genes related to dopaminergic and serotonergic systems, and other personality variables.
resultsWe found that emotional stability and its subdimensions are genetically associated with MAOA-uVNTR polymorphism. Thus, women carriers of the 3-repeat allele (lower MAO-A expression) showed higher levels of emotional stability. No associations were found with other polymorphisms analyzed, including COMT Val
conclusionOur results indicate that neuroticism might be regulated by MAOA and could be a common factor between different phenotypes, such as aggressive behaviors or personality disorders, observed in women with higher activity genotype who had been exposed to negative environments during childhood. This study could lead to a better understanding of the basis of emotional stability and could lead to future projects for this purpose.
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