Evidence map›Paper›PMID 31448507›Full record

ArticleInternational wound journal2019

Factors associated with lower-extremity amputation in patients with diabetic foot ulcers in a Chinese tertiary care hospital.

Zi Guo, Chun Yue, Qiang Qian, Honghui He, Zhaohui Mo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  5. Predictors of Unfavorable Outcomes in Diabetic Foot Ulcers.Diagnostics (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zi GuoDepartment of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0002-2295-0213
Chun YueDepartment of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, China.
Qiang QianDepartment of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, China.
Honghui HeDepartment of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhaohui MoDepartment of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CN

Funding

National Natural Science Foundation of China 81670769New Xiangya Talent Project of the Third Xiangya hospital of Central South University 20150307New Xiangya Talent Project of the Third Xiangya hospital of Central South University JY201717
6 · The paper itself

Abstract

Providing a better understanding of the risk factors for amputation in this particular region, Hunan province, in China might help patients with diabetic foot ulcers receive timely and appropriate medical care and help prevent amputation. Diabetic foot ulcer patients referred to the Third Xiangya Hospital during the period between December 2014 and September 2018 were enrolled. Participants who underwent amputations and received conservative treatments were compared using univariate and multivariate analyses to identify the independent predictors of amputation. Those who required amputation presented significantly higher levels of white blood cell counts, platelet counts, erythrocyte sedimentation rate, C-reactive protein, and glycated haemoglobin (HbA1c) levels. However, levels of haemoglobin, postprandial plasma C-peptide, triglyceride, high-density lipoprotein cholesterol, albumin, and uric acid were decreased in patients with amputations. Patients with more advanced Wagner grades had much higher rates of amputation. Multivariable-adjusted odds ratios in stepwise logistic regression model was 1.317 for HbA1c (95% CI: 1.015-1.709), 0.255 for triglyceride (95% CI: 0.067-0.975), and 20.947 for Wagner grades (95% CI: 4.216-104.080). Independent risk factors for amputation in these Chinese diabetic foot ulcer patients included an elevated HbA1c level, lower triglyceride level, and higher Wagner grades.

Indexed as

Amputation, SurgicalAdolescentAdultAgedAged, 80 and overBlood SedimentationChinaC-Reactive ProteinDiabetic FootFemaleGlycated HemoglobinHumansLeukocyte CountLower ExtremityMaleMiddle AgedC-Reactive ProteinGlycated Hemoglobinhemoglobin A1c protein, humanTriglyceridesamputationChinadiabetic footrisk factors

Identifiers

PMID31448507
PMCPMC7949440
OpenAlexW2970568729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.