ArticleMedical physics2019
Current pediatric administered activity guidelines for
Article in Medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Fabrication Process and Particle Dispersion Characteristics of W-PETG-Based 3D-Printed Composites for Medical Radiation Shielding.Polymers · 2026Article
- Weight-based determination of administered activity inPediatric radiology · 2025Article
- Girth-based administered activity for pediatricMedical physics · 2024Article
- RenalEJNMMI physics · 2021Article
- DeepAMO: a multi-slice, multi-view anthropomorphic model observer for visual detection tasks performed on volume images.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- Body morphometry appropriate computational phantoms for dose and risk optimization in pediatric renal imaging with Tc-99m DMSA and Tc-99m MAG3.Physics in medicine and biology · 2020Article
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Authors and funding
12 authors.
Funding
Abstract
purposeIn the current clinical practice, administered activity (AA) for pediatric molecular imaging is often based on the North American expert consensus guidelines or the European Association of Nuclear Medicine dosage card, both of which were developed based on the best clinical practice. These guidelines were not formulated using a rigorous evaluation of diagnostic image quality (IQ) relative to AA. In the guidelines, AA is determined by a weight-based scaling of the adult AA, along with minimum and maximum AA constraints. In this study, we use task-based IQ assessment methods to rigorously evaluate the efficacy of weight-based scaling in equalizing IQ using a population of pediatric patients of different ages and body weights.
methodsA previously developed projection image database was used. We measured task-based IQ, with respect to the detection of a renal functional defect at six different AA levels (AA relative to the AA obtained from the guidelines). IQ was assessed using an anthropomorphic model observer. Receiver-operating characteristics (ROC) analysis was applied; the area under the ROC curve (AUC) served as a figure-of-merit for task performance. In addition, we investigated patient girth (circumference) as a potential improved predictor of the IQ.
resultsThe data demonstrate a monotonic and modestly saturating increase in AUC with increasing AA, indicating that defect detectability was limited by quantum noise and the effects of object variability were modest over the range of AA levels studied. The AA for a given value of the AUC increased with increasing age. The AUC vs AA plots for all the patient ages indicate that, for the current guidelines, the newborn and 10- and 15-yr phantoms had similar IQ for the same AA suggested by the North American expert consensus guidelines, but the 5- and 1-yr phantoms had lower IQ. The results also showed that girth has a stronger correlation with the needed AA to provide a constant AUC for
conclusionsThe results suggest that (a) weight-based scaling is not sufficient to equalize task-based IQ for patients of different weights in pediatric
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