Evidence map›Paper›PMID 31448407›Full record

ArticleThe Journal of physiology2019

Precapillary pulmonary gas exchange is similar for oxygen and inert gases.

Michael K Stickland, Vincent Tedjasaputra, Desi P Fuhr, Harrieth E Wagner, Sophie É Collins, Bradley W Byers, Peter D Wagner, Susan R Hopkins

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Michael K SticklandDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, AB, Canada.ORCID 0000-0001-8234-4760
Vincent TedjasaputraDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, AB, Canada.
Desi P FuhrDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, AB, Canada.
Harrieth E WagnerDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA.
Sophie É CollinsDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, AB, Canada.ORCID 0000-0002-6323-1127
Bradley W ByersDivision of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, AB, Canada.
Peter D WagnerDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA.
Susan R HopkinsDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA.
University of Alberta · CAUniversity of California System · US

Funding

Imaging Blood Flow, Ventilation, and Density InteractionsR01HL119201 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.5M
Imaging Hypoxic Pulmonary Vasoconstriction in the Aging Lung with Proton MRIR01HL129990 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.4M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
UV Safe: New approaches to reduce teen UV exposureR21CA119201 · NCI · DARTMOUTH COLLEGE · PI OLSON, ARDIS L · 2006 to 2007
$330k
NHLBI NIH HHS R01 HL119201NHLBI NIH HHS R01 HL129990
6 · The paper itself

Abstract

key pointsPrecapillary gas exchange for oxygen has been documented in both humans and animals. It has been suggested that, if precapillary gas exchange occurs to a greater extent for inert gases than for oxygen, shunt and its effects on arterial oxygenation may be underestimated by the multiple inert gas elimination technique (MIGET). We evaluated fractional precapillary gas exchange in canines for O ABSTRACT: Some pulmonary gas exchange is known to occur proximal to the pulmonary capillary, although the magnitude of this gas exchange is uncertain, and it is unclear whether oxygen and inert gases are similarly affected. This has implications for measuring shunt and associated gas exchange consequences. By measuring respiratory and inert gas levels in the proximal pulmonary artery (P), a distal pulmonary artery 1 cm proximal to the wedge position (using a 5-F catheter) (D) and a systemic artery (A), we evaluated precapillary gas exchange in 27 paired samples from seven anaesthetized, ventilated canines. Fractional precapillary gas exchange (F) was quantified for each gas as F = (P - D)/(P - A). The lowest solubility inert gases, sulphur hexafluoride (SF

Indexed as

AnimalsDogsLungNoble GasesOxygenPulmonary CirculationPulmonary Gas ExchangeNoble GasesOxygeninert gaspulmonary circulationpulmonary gas exchangeshunt

Identifiers

PMID31448407
PMCPMC6858488
OpenAlexW2970521115

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.