Evidence map›Paper›PMID 31448392›Full record

Trial reportMusculoskeletal surgery2020

PRP versus steroids in a deadlock for efficacy: long-term stability versus short-term intensity-results from a randomised trial.

P Kumar Gupta, A Acharya, V Khanna, S Roy, K Khillan, S Nathan Sambandam

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Musculoskeletal surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

P Kumar GuptaDepartment of Sports Medicine, Sir Ganga Ram Hospital, New Delhi, India. sportsmedicineresearch@gmail.com.ORCID http://orcid.org/0000-0002-0671-8174
A AcharyaDepartment of Sports Medicine, Sir Ganga Ram Hospital, New Delhi, India.
V KhannaDepartment of Orthopaedics, Sir Ganga Ram Hospital, New Delhi, India.
S RoyDepartment of Sports Medicine, Sir Ganga Ram Hospital, New Delhi, India.
K KhillanDepartment of Blood Transfusion Medicine, Sir Ganga Ram Hospital, New Delhi, India.
S Nathan SambandamDepartment of Orthopedics, Louis A Johnson VA Medical Center, Clarksburg, WV, USA.
Sir Ganga Ram Hospital · INLouis A. Johnson VA Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA popular choice for lateral epicondylitis (LE), corticosteroid injections have been associated with prominent side effects, which has led to the conception of modalities like platelet-rich plasma (PRP). This randomised trial aimed to evaluate and compare the 6-week, 3-month and 1-year outcomes with PRP and corticosteroid injections in LE. We hypothesised that PRP would prove more effective in relieving pain and improving function.

methodsAt the sports medicine unit of our tertiary care teaching centre, 80 patients with LE were randomised into either receiving PRP (group A) or corticosteroids (group B) injections. Pre-injection visual analogue scale (VAS), disabilities of the arm, shoulder and hand (DASH) score, Mayo elbow performance score (MEPS) and grip strength score (GSS) were recorded. Common extensor origins were identified and infiltrated with 3 ml of either PRP or corticosteroid (triamcinolone in 2% xylocaine) using a peppering technique. Follow-up scores and extent of pain relief were recorded and compared.

resultsAt 6 weeks, there were greater improvements in group B versus A in mean VAS (13.8 vs. 44.5; p < 0.001), DASH (64.2 vs. 53.3; p < 0.001), MEPS (88.0 vs. 74.5; p = 0.004) and GSS (89.3 vs. 73.4; p = 0.039). These scores showed a reversed pattern at 3 months when group A outcomes superseded group B (VAS p = 0.002; DASH p < 0.001; MEPS p = 0.002; GSS p = 0.045). At 1-year follow-up, group A continued to enjoy better pain relief and function (VAS p = 0.024; DASH p < 0.001; MEPS p = 0.009; GSS p = 0.028).

conclusionsAlbeit corticosteroid injections show good short-term results at 6 weeks, patients receiving PRP injections fare better at 3 and 12 months.

Indexed as

Platelet-Rich PlasmaAdrenal Cortex HormonesAdultAnti-Inflammatory AgentsFemaleHand StrengthHumansInjections, Intra-ArticularLidocaineMaleMiddle AgedPain ManagementPain MeasurementProspective StudiesTennis ElbowTertiary Care CentersAdrenal Cortex HormonesAnti-Inflammatory AgentsLidocaineTriamcinoloneCorticosteroid injectionsElbow functionElbow injectionsHandgrip strengthsPain reliefPlatelet-rich plasma injections

Identifiers

PMID31448392
OpenAlexW2971007949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.