Evidence map›Paper›PMID 31448322›Full record

ArticleScience advances2019

Genomic determinants of speciation and spread of the

Á Chiner-Oms, L Sánchez-Busó, J Corander, S Gagneux, S R Harris, D Young, F González-Candelas, I Comas

Open access · goldAbstract readHistorical Article
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
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  6. Gene conversion is a key driver of diversity hotspots inbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Review
  9. Population structure and spatial distribution ofFrontiers in microbiology · 2026
    Article
  10. Article
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  12. Review
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  15. Article
  16. Review
  17. Article
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Á Chiner-OmsUnidad Mixta "Infección y Salud Pública" FISABIO-CSISP/Universidad de Valencia, Instituto de Biología Integrativa de Sistemas (ISysBio), Valencia, Spain.ORCID 0000-0002-0463-0101
L Sánchez-BusóPathogen Genomics, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.ORCID 0000-0002-4162-0228
J CoranderPathogen Genomics, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.ORCID 0000-0002-7752-1942
S GagneuxSwiss Tropical and Public Health Institute, Basel, Switzerland.ORCID 0000-0001-7783-9048
S R HarrisMicrobiotica, BioData Innovation Centre, Wellcome Genome Campus, Cambridge CB10 1DR, UK.ORCID 0000-0003-1512-6194
D YoungThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
F González-CandelasUnidad Mixta "Infección y Salud Pública" FISABIO-CSISP/Universidad de Valencia, Instituto de Biología Integrativa de Sistemas (ISysBio), Valencia, Spain.ORCID 0000-0002-0879-5798
I ComasCIBER en Epidemiología y Salud Pública, Valencia, Spain.ORCID 0000-0001-5504-9408
Institute for Integrative Systems Biology · ESInstituto de Biomedicina de Valencia · ESSwiss Tropical and Public Health Institute · CHThe Francis Crick Institute · GBUniversity of Helsinki · FIWellcome Sanger Institute · GBWellcome Trust · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Models on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze the population genomics events leading to the emergence of the tuberculosis pathogen. The emergence is characterized by a combination of recombination events involving core pathogenesis functions and purifying selection on early diverging loci. We identify the

Indexed as

Genome, BacterialBacterial ProteinsDatasets as TopicGene ExpressionGenetic LociGenetic SpeciationHistory, 21st CenturyHistory, AncientHost-Pathogen InteractionsHumansMutationMycobacteriumMycobacterium tuberculosisPhylogenyRecombination, GeneticSelection, GeneticBacterial ProteinsPhoR protein, BacteriaVirulence Factors

Identifiers

PMID31448322
PMCPMC6691555
OpenAlexW2951724376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.