ArticleAdvanced materials technologies2019
The Unusual Properties of Polytetrafluoroethylene Enable Massive-Volume Vitrification of Stem Cells with Low-Concentration Cryoprotectants.
Article in Advanced materials technologies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Dimethyl sulfoxide in cryopreserved mesenchymal stromal cell therapy products: is there a safety risk to patients?Journal of translational medicine · 2025Review
- High-Throughput Encapsulation of Stem Cells: Characterizing Dynamic Culture Variability With a Millifluidic Approach.Advanced healthcare materials · 2025Article
- Reconfigurable Tri-Mode Metasurface for Broadband Low Observation, Wide-Range Tracing, and Backscatter Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Conduction-Dominated Cryomesh for Organism Vitrification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Eco-friendly screen printing of silver nanowires for flexible and stretchable electronics.Nanoscale · 2023Article
- Cryopreservation of Tissue-Engineered Scaffold-Based Constructs: from Concept to Reality.Stem cell reviews and reports · 2022Review
- Development of a Vitrification Preservation Process for Bioengineered Epithelial Constructs.Cells · 2022Article
- Magnetic Nanoparticle-Mediated Heating for Biomedical Applications.Journal of heat transfer · 2022Article
- Vitrification and Rewarming of Magnetic Nanoparticle-Loaded Rat Hearts.Advanced materials technologies · 2022Article
- Electrical aspects of skin as a pathway to engineering skin devices.APL bioengineering · 2021Review
- Sand-mediated ice seeding enables serum-free low-cryoprotectant cryopreservation of human induced pluripotent stem cells.Bioactive materials · 2021Article
- Conduction Cooling and Plasmonic Heating Dramatically Increase Droplet Vitrification Volumes for Cell Cryopreservation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Ice Inhibition for Cryopreservation: Materials, Strategies, and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- High-performance printed electronics based on inorganic semiconducting nano to chip scale structures.Nano convergence · 2020Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Injectable stem cell-hydrogel constructs hold great potential for regenerative medicine and cell-based therapies. However, their clinical application is still challenging due to their short shelf-life at ambient temperature and the time-consuming fabrication procedure. Banking the constructs at cryogenic temperature may offer the possibility of "off-the-shelf" availability to end-users. However, ice formation during the cryopreservation process may compromise the construct quality and cell viability. Vitrification, cooling biological samples without apparent ice formation, has been explored to resolve the challenge. However, contemporary vitrification methods are limited to very small volume (up to ~0.25 ml) and/or need highly toxic and high concentration (up to ~8 M) of permeable cryoprotectants (pCPAs). Here, we show that polytetrafluoroethylene (PTFE, best known as Teflon for making non-stick cookware) capillary is flexible and unusually stable at a cryogenic temperature. By using the PTFE capillary as a flexible cryopreservation vessel together with alginate hydrogel microencapsulation and Fe
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.