ReviewFrontiers in cardiovascular medicine2019
Platelet Function in Aging.
Review in Frontiers in cardiovascular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06687824 (Evaluation of the Effect of Black Tea Extract-Impregnated Gauze on Primary Bleeding Cessation After Molar Extraction), which is not on this map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effect of Black Tea Extract-Impregnated Gauze on Primary Bleeding Cessation After Molar Extraction: A Randomized Controlled Trial
Who cites it
73 citing papers in PubMed, 119 citations in OpenAlex.
- Platelet-platelet aggregates at single-event resolution as parameter in health monitoring.Biochemistry and biophysics reports · 2026Article
- Age-Related Platelet Cox-1 Upregulation in Atrial Fibrillation.International journal of molecular sciences · 2026Article
- Platelet Mitochondrial Function, Physical Performance, and Body Composition in Older People Living with HIV: A Preliminary Study.International journal of molecular sciences · 2026Article
- Platelet Hyperreactivity and Risk of Ischemic Placental Disease: A Prospective Cohort Study.Pregnancy (Hoboken, N.J.) · 2026Article
- Incidence and outcomes of major bleeding among first-time oral factor Xa inhibitor users: multinational observational cohort studies.Research and practice in thrombosis and haemostasis · 2026Article
- Platelet-Rich Plasma from the Research to the Clinical Arena: A Journey Toward the Precision Regenerative Medicine.International journal of molecular sciences · 2026Review
- Native Platelet Function and Clinical Outcomes in Very Elderly Patients: A Retrospective Cohort Study.Clinical interventions in aging · 2026Article
- Enhanced risk of thrombosis in aged insulin-treated diabetic rats exposed to non-severe recurrent hypoglycemia.Diabetology & metabolic syndrome · 2025Article
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- Article
- Comparative photobiomodulatory effects of 660 nm, 810 nm, and 940 nm diode lasers on platelet-rich fibrin: an ex vivo study on structural remodeling and VEGF/PDGF-BB release for enhanced periodontal healing.Lasers in medical science · 2025Article
- Influence of age and sex on platelet count: Implications for optimizing growth factor-rich plasma preparation.Journal of clinical and experimental dentistry · 2025Review
- Sex-related differences in platelet aggregation: rebuttal to reply.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Potential Noninvasive Biomarkers to Assess the Aging Process.Expert reviews in molecular medicine · 2025Review
- Attachment orientation and platelet activity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Review
- Direct megakaryopoiesis.Current opinion in hematology · 2025Review
- Effects of Regular Habitual Exercise on Platelet Energetics in Male Recreational Contact Sports Student-Athletes: A Cross-Sectional Study.Health science reports · 2025Article
- Aging-associated changes in immunological parameters: Implications for COVID-19 immune response in the elderly.Physiological reports · 2025Review
- Effects of exercise on cAMP-mediated platelet inhibition in young women: a pilot study.European journal of applied physiology · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.