Evidence map›Paper›PMID 31448288›Full record

ArticleFrontiers in cardiovascular medicine2019

A Preliminary Computational Investigation Into the Flow of PEG in Rat Myocardial Tissue for Regenerative Therapy.

Malebogo Ngoepe, Andreas Passos, Stavroula Balabani, Jesse King, Anastasia Lynn, Jasanth Moodley, Liam Swanson, Deon Bezuidenhout, Neil H Davies, Thomas Franz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Malebogo NgoepeDepartment of Mechanical Engineering, University of Cape Town, Rondebosch, South Africa.
Andreas PassosDepartment of Mechanical Engineering, University College London, London, United Kingdom.
Stavroula BalabaniDepartment of Mechanical Engineering, University College London, London, United Kingdom.
Jesse KingDepartment of Mechanical Engineering, University of Cape Town, Rondebosch, South Africa.
Anastasia LynnDepartment of Mechanical Engineering, University of Cape Town, Rondebosch, South Africa.
Jasanth MoodleyDepartment of Mechanical Engineering, University of Cape Town, Rondebosch, South Africa.
Liam SwansonDepartment of Mechanical Engineering, University of Cape Town, Rondebosch, South Africa.
Deon BezuidenhoutCardiovascular Research Unit, Department of Surgery, University of Cape Town, Observatory, South Africa.
Neil H DaviesCardiovascular Research Unit, Department of Surgery, University of Cape Town, Observatory, South Africa.
Thomas FranzDivision of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory, South Africa.
University of Cape Town · ZAUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI), a type of cardiovascular disease, affects a significant proportion of people around the world. Traditionally, non-communicable chronic diseases were largely associated with aging populations in higher income countries. It is now evident that low- to middle-income countries are also affected and in these settings, younger individuals are at high risk. Currently, interventions for MI prolong the time to heart failure. Regenerative medicine and stem cell therapy have the potential to mitigate the effects of MI and to significantly improve the quality of life for patients. The main drawback with these therapies is that many of the injected cells are lost due to the vigorous motion of the heart. Great effort has been directed toward the development of scaffolds which can be injected alongside stem cells, in an attempt to improve retention and cell engraftment. In some cases, the scaffold alone has been seen to improve heart function. This study focuses on a synthetic polyethylene glycol (PEG) based hydrogel which is injected into the heart to improve left ventricular function following MI. Many studies in literature characterize PEG as a Newtonian fluid within a specified shear rate range, on the macroscale. The aim of the study is to characterize the flow of a 20 kDa PEG on the microscale, where the behavior is likely to deviate from macroscale flow patterns. Micro particle image velocimetry (μPIV) is used to observe flow behavior in microchannels, representing the gaps in myocardial tissue. The fluid exhibits non-Newtonian, shear-thinning behavior at this scale. Idealized two-dimensional computational fluid dynamics (CFD) models of PEG flow in microchannels are then developed and validated using the μPIV study. The validated computational model is applied to a realistic, microscopy-derived myocardial tissue model. From the realistic tissue reconstruction, it is evident that the myocardial flow region plays an important role in the distribution of PEG, and therefore, in the retention of material.

Indexed as

computational fluid dynamicsinjectate therapymyocardial infarctionparticle image velocimetrypolyethylene glycol hydrogelretention

Identifiers

PMID31448288
PMCPMC6692440
OpenAlexW2956563168

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.