ArticleQuantitative imaging in medicine and surgery2019
Early prediction of acute xerostomia during radiation therapy for nasopharyngeal cancer based on delta radiomics from CT images.
Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01762514 (A Multi-institutional, Randomized Parallel Controlled, Phase II Clinical Trial on Comparison of Effectiveness and Safeness of Amifostine Every-other-day Regimen and Everyday Regimen From Monday to Friday), which is not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-institutional, Randomized Parallel Controlled, Phase II Clinical Trial on Comparison of Effectiveness and Safeness of Amifostine Every-other-day Regimen and Everyday Regimen From Monday to Friday
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients.The Cochrane database of systematic reviews · 2025Pooled it
- Delta radiomics: a systematic review.La Radiologia medica · 2021Pooled it
- Article
- A Pilot Study of Multimodal Dosiomics and Longitudinal Delta-Radiomics for Predicting Radiation-Induced Xerostomia in Head-and-Neck Cancer.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Longitudinal multi-b-value diffusion MRI for the early assessment of radiation-induced parotid injury in nasopharyngeal carcinoma.Frontiers in oncology · 2026Article
- CNN-based prediction using early post-radiotherapy MRI as a proxy for toxicity in the murine head and neck.Acta oncologica (Stockholm, Sweden) · 2025Article
- Performance of MRI-based radiomics for prediction of residual disease status in patients with nasopharyngeal carcinoma after radical radiotherapy.Scientific reports · 2025Article
- Ensemble learning approach for prediction of early complications after radiotherapy for head and neck cancer using CT and MRI radiomic features.Scientific reports · 2025Article
- Vocal Cord Dysfunction in Nonlaryngeal Head and Neck Cancer After Chemoradiation Therapy: Predictive Modeling Using CT Radiomics and Machine Learning.BioMed research international · 2025Article
- The value of T1- and FST2-Weighted-based radiomics nomogram in differentiating pleomorphic adenoma and Warthin tumor.Translational oncology · 2024Article
- Radiomics approach for identifying radiation-induced normal tissue toxicity in the lung.Scientific reports · 2024Article
- Artificial Intelligence in Head and Neck Surgery.Otolaryngologic clinics of North America · 2024Review
- Cone beam computed tomography (CBCT) and megavoltage computed tomography (MVCT)-based radiomics in head and neck cancers: a systematic review and radiomics quality score assessment.Quantitative imaging in medicine and surgery · 2024Review
- Article
- Article
- Interobserver delineation variability of computed tomography-based radiomic features of the parotid gland.Radiation oncology journal · 2024Article
- Predictive value of delta radiomics in xerostomia after chemoradiotherapy in patients with stage III-IV nasopharyngeal carcinoma.Radiation oncology (London, England) · 2024Article
- Article
- CT-based peritumoral radiomics nomogram on prediction of response and survival to induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma.Journal of cancer research and clinical oncology · 2024Article
- A quantitative CBCT pipeline based on 2D antiscatter grid and grid-based scatter sampling for image-guided radiation therapy.Medical physics · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute xerostomia is the most common side effect of radiation therapy (RT) for head and neck (H&N) malignancies. Investigating radiation-induced changes of computed tomography (CT) radiomics in parotid glands (PGs) and saliva amount (SA) can predict acute xerostomia during the RT for nasopharyngeal cancer (NPC).
methodsCT and SA data from 35 patients with stages I-IVB were randomly collected from an NPC clinical trial registered on the clinicaltrials.gov (ID: NCT01762514). All patients received radical treatment based on intensity-modulated RT (IMRT) with a prescription dose of 68.1 Gy in 30 fractions. The patients' ages ranged 24-72 years, and each patient had five CT sets acquired at treatment position: at the 0
resultsSubstantial changes in various radiomics metrics of PGs were observed during the RT. Eight normalized feature value (NFV), selected from NFV
conclusionsThis study demonstrated that radiation-induced acute xerostomia level could be early predicted based on the SA and radiomics changes of the PGs during IMRT delivery. SA, NFV
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.