ReviewGlobal spine journal2019
Biomarkers of Ossification of the Spinal Ligament.
Review in Global spine journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between diabetes mellitus and ossification of the spinal ligament: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Article
- Musculoskeletal biomarkers in health and disease: implications for the aging spine-a review for spinal surgeons by the SRS adult spinal deformity task force on senescence.Spine deformity · 2025Review
- The relationship between OPLL and metabolic disorders.Bone research · 2025Review
- Proteomic analysis and effects on osteogenic differentiation of exosomes from patients with ossification of the spinal ligament.JBMR plus · 2025Article
- High Body Mass Index Is Associated with an Increased Risk of the Onset and Severity of Ossification of Spinal Ligaments.Frontiers in surgery · 2022Article
- Biomarker Research Approach to the Pathogenesis of Ossification of the Spinal Ligament: A Review.Spine surgery and related research · 2022Review
- Contribution of Glycation and Oxidative Stress to Thyroid Gland Pathology-A Pilot Study.Biomolecules · 2021Article
- Identification of the molecular mechanism and diagnostic biomarkers in the thoracic ossification of the ligamentum flavum using metabolomics and transcriptomics.BMC molecular and cell biology · 2020Article
- Serum Periostin Level Reflects Progression of Ossification of the Posterior Longitudinal Ligament.JB & JS open accessArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designLiterature review.
objectivesTo review biomarkers in patients with ossification of the spinal ligament (OSL), including ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum and to raise the present issues.
methodsA literature search was performed using PubMed and MEDLINE databases. The biomarkers were classified according to category. The number of the subjects and reproducibility were assessed.
resultsEleven articles were included in this review. There were 9 articles from Japan, 1 article from Taiwan, and 1 article from China. The biomarkers were classified into calcium-phosphate metabolism markers, bone turnover markers, sclerostin, dickkopf-1, secreted frizzled-related protein-1, fibroblast growth factor-23, fibronectin, menatetrenone, leptin, pentosidine, and hypersensitive C-reactive protein. However, there were several limitations in the research studies, such as small research field, small number of subjects, and a lack of reproducibility.
conclusionsAlthough there have been several studies that have analyzed biomarkers for OSL, there are no definitive conclusions to date. Numerous issues will need to be resolved in the future. It is imperative to continue this research because the results might prove beneficial to elucidate the pathology of OSL and the measures to prevent the initiation and progression of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.