Evidence map›Paper›PMID 31447949›Full record

ArticlePolymer chemistry2019

Sequential Nucleophilic "Click" Reactions for Functional Amphiphilic Homopolymers.

Huan He, Bin Liu, Meizhe Wang, Richard W Vachet, S Thayumanavan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Huan HeDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003.
Bin LiuDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003.
Meizhe WangDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003.
Richard W VachetDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003.
S ThayumanavanDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003.
Amherst College · US

Funding

Supramolecular Assemblies for Detecting Biomarkers in Complex MixturesR01CA169140 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THAYUMANAVAN, SANKARAN · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA169140
6 · The paper itself

Abstract

Amphiphilic homopolymers with high densities of functional groups are synthetically challenging. Thiol-yne nucleophilic click reactions have been investigated to introduce multiple functional groups in polymers with high density. An electron deficient alkyne group bearing methacrylate monomer was polymerized using reversible addition-fragmentation chain-transfer (RAFT) polymerization. Subsequently, the electron deficient alkyne group on polymer side chain was readily reacted with a thiol reagent using triethylamine (TEA) as the organocatalyst. This reaction was found to be very efficient under mild conditions. The resultant homopolymer bearing thiol vinyl ether functional groups could perform a second thiol addition with a stronger base, such as triazabicyclodecene (TBD), to prepare multifunctional homopolymers. This stepwise addition process was monitored by

Indexed as

Activated alkynemulti-functionalitysequential nucleophilic additionthiol-yne click reaction

Identifiers

PMID31447949
PMCPMC6707748
OpenAlexW2901557577

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.