Evidence map›Paper›PMID 31447935›Full record

ArticleTherapeutic advances in neurological disorders2019

The prevalence of intracranial stenosis in patients at low and moderate risk of stroke.

Hong-Xiu Chen, Li-Juan Wang, Yi Yang, Fei-Xue Yue, Li-Min Chen, Ying-Qi Xing

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in neurological disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07156344 (An Observational Cohort Study on the Identification and Outcome Evaluation of Intracranial Atherosclerotic Plaque Vulnerability), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07156344 completednot on this map

An Observational Cohort Study on the Identification and Outcome Evaluation of Intracranial Atherosclerotic Plaque Vulnerability

TypeobservationalSponsorXuanwu Hospital, BeijingRan2019 to 2025Enrolled3,849ConditionsAsymptomatic Intracranial Atherosclerotic Stenosis PatientsArmsProgression and Outcome of Intracranial Atherosclerosis
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. RETRACTED: Rescue intracranial stenting in acute ischemic stroke (study).Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hong-Xiu ChenDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Li-Juan WangDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Yi YangDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Fei-Xue YueDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Li-Min ChenDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Ying-Qi XingDepartment of Neurology, The First Hospital of Jilin University, Xinmin Street 71, Changchun 130021, China.ORCID https://orcid.org/0000-0003-0680-1821
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies assessing the risk of stroke in the general population performed screening with Doppler ultrasonography only for high-risk patients and neglected low- and moderate-risk patients. The aims of this study were to explore the current prevalence of intracranial arterial stenosis (ICAS) and analyze its association with different levels of stroke risk and risk factors based on the risk assessment scale for stroke used in China.

methodsA total of 3654 participants who underwent transcranial Doppler ultrasound (TCD) were eligible for inclusion. Information regarding demographic characteristics and risk factors such as alcohol consumption and hypertension was collected through interviews and questionnaires and used to analyze the association of ICAS with different levels of stroke risk and risk factors.

resultsThe mean age of 501 subjects diagnosed with at least one ICAS was higher than that of participants without ICAS (57.13 ± 9.56 years and 55.52 ± 9.35 years, respectively). After adjusting for confounding factors, gender, education, residence, hypertension and personal history of stroke were associated with ICAS. The odds ratios for ICAS in patients with hypertension and a personal history of stroke were 1.655 [95% confidence interval (CI): 1.341-2.043] and 1.854 (95% CI: 1.371-2.508), respectively. In addition, participants in the low- and moderate-risk stroke groups accounted for an unexpectedly high proportion of individuals with ICAS (up to 38.3%). Results from multivariate analyses indicated that the adjusted odds ratios for ICAS in patients with moderate and high stroke risks

conclusionThe prevalence of ICAS is high in northeast China and increases with the level of stroke risk. However, the proportion of patients with ICAS among those with low and moderate stroke risks should also be noted.

Indexed as

intracranial arterial stenosisrisk factorstroke screeningtranscranial Doppler ultrasound

Identifiers

PMID31447935
PMCPMC6693021
OpenAlexW2968198624

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.