Evidence map›Paper›PMID 31447925›Full record

ArticleJournal of the Intensive Care Society2019

A case of sinus pause induced by swallowing in the setting of olanzapine and guanfacine overdose.

Andrew R Kolarich, Matthew Mubarak, Shannon Wells, Christopher T Campbell, Ravi S Samraj

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Intensive Care Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrew R KolarichUniversity of Florida College of Medicine, Gainesville, FL, USA.
Matthew MubarakPediatric Critical Care Medicine, University of Florida, UF Health Shands Children's Hospital, Gainesville, FL, USA.
Shannon WellsPediatric Critical Care Medicine, University of Florida, UF Health Shands Children's Hospital, Gainesville, FL, USA.
Christopher T CampbellCollege of Pharmacy, University of Florida, Gainesville, FL, USA.
Ravi S SamrajPediatric Critical Care Medicine, University of Florida, UF Health Shands Children's Hospital, Gainesville, FL, USA.
University of Florida · USFlorida College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olanzapine, a second-generation antipsychotic, is used in both adult and pediatric populations for schizophrenia, bipolar disorder, and depression and has been associated with autonomic dysregulation in the setting of overdose. Guanfacine is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder and has also been associated with autonomic dysfunction. We present a unique case of a 17-year-old male who overdosed on 340 mg of olanzapine and 189 mg of extended-release guanfacine with a previously unreported adverse event. Specifically, five days after ingestion, he developed a 5-8 s sinus pause every time he forcefully swallowed any beverage, suggestive of a vagal hypersensitivity reaction. The report will review the autonomic dysfunction of olanzapine and guanfacine and management of asymptomatic sinus pause in the critical care setting.

Indexed as

attention deficit and disruptive behavior disorderscardiacdrug overdoseguanfacineolanzapineSinus arrest

Identifiers

PMID31447925
PMCPMC6693107
OpenAlexW2878459383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.