Evidence map›Paper›PMID 31447885›Full record

ArticleFrontiers in genetics2019

Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer.

Elena A Pudova, Elena N Lukyanova, Kirill M Nyushko, Dmitry S Mikhaylenko, Andrew R Zaretsky, Anastasiya V Snezhkina, Maria V Savvateeva, Anastasiya A Kobelyatskaya, Nataliya V Melnikova, Nadezhda N Volchenko and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Consistent DNA Hypomethylations in Prostate Cancer.International journal of molecular sciences · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Frontiers in genetics · 2020
    Article
  19. Article
  20. Amino Acid Transporter SLC6A14 (ATBFrontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Elena A PudovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Elena N LukyanovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Kirill M NyushkoNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Dmitry S MikhaylenkoNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Andrew R ZaretskyEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasiya V SnezhkinaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Maria V SavvateevaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasiya A KobelyatskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Nataliya V MelnikovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Nadezhda N VolchenkoNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Gennady D EfremovNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Kseniya M KliminaVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Anastasiya A BelovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Marina V KiselevaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Andrey D KaprinNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Boris Y AlekseevNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
George S KrasnovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anna V KudryavtsevaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Engelhardt Institute of Molecular Biology · RUMinistry of Health of the Russian Federation · RUSechenov University · RUVavilov Institute of General Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Older age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association between older age and disease onset. Carcinogenesis is followed by the deregulation of many genes, and some of these changes could serve as biomarkers for diagnosis, prognosis, prediction of drug therapy efficacy, as well as possible therapeutic targets. We have performed a bioinformatic analysis of a The Cancer Genome Atlas (TCGA) data and RNA-Seq profiling of a Russian patient cohort to reveal prognostic markers of locally advanced lymph node-negative prostate cancer (lymph node-negative LAPC). We also aimed to identify markers of the most common molecular subtype of prostate cancer carrying a fusion transcript

Indexed as

locally advanced prostate cancerprognostic markersRNA-SeqTCGATMPRSS2-ERG

Identifiers

PMID31447885
PMCPMC6697060
OpenAlexW2957158730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.