Evidence map›Paper›PMID 31447864›Full record

ArticleFrontiers in immunology2019

T Cells Control Chemokine Secretion by Keratinocytes.

Tabea Rauschenberger, Viola Schmitt, Muhammad Azeem, Stefan Klein-Hessling, Krisna Murti, Franziska Grän, Matthias Goebeler, Andreas Kerstan, Matthias Klein, Tobias Bopp and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Immunology of Psoriasis-Current Concepts in Pathogenesis.Clinical reviews in allergy & immunology · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. The Immune Functions of Keratinocytes in Skin Wound Healing.International journal of molecular sciences · 2020
    Review
  13. Current Developments in the Immunology of Psoriasis.The Yale journal of biology and medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tabea RauschenbergerDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Viola SchmittDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Muhammad AzeemDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Stefan Klein-HesslingDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Krisna MurtiDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Franziska GränDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Matthias GoebelerDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Andreas KerstanDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Matthias KleinInstitute for Immunology, University Medical Center, University of Mainz, Mainz, Germany.
Tobias BoppInstitute for Immunology, University Medical Center, University of Mainz, Mainz, Germany.
Edgar SerflingDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Khalid MuhammadDepartment of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
University of Würzburg · DEUniversitätsklinikum Würzburg · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The massive infiltration of lymphocytes into the skin is a hallmark of numerous human skin disorders. By co-culturing murine keratinocytes with splenic T cells we demonstrate here that T cells affect and control the synthesis and secretion of chemokines by keratinocytes. While pre-activated CD8

Indexed as

AnimalsCD40 LigandCells, CulturedChemokinesCoculture TechniquesFemaleGene Expression ProfilingKeratinocytesMaleMice, Inbred C57BLMice, TransgenicProgrammed Cell Death 1 ReceptorSkinT-LymphocytesCD40 LigandChemokinesPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorchemokineIFNkeratinocyteslichen planusNfatc1T cells

Identifiers

PMID31447864
PMCPMC6696622
OpenAlexW2965280638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.